Organic compounds labeled with hydrogen isotopes play a crucial role in numerous areas,
from materials science to medicinal chemistry. Indeed, while the replacement of hydrogen by …

In a symmetric hydrogen bond (H-bond), the hydrogen atom is perfectly centered between
the two donor atoms. The energy diagram for hydrogen motion is thus a single-well …

The concept of isosterism between relatively simple chemical entities was originally
contemplated by James Moir in 1909, a notion further refined by HG Grimm's hydride …

An experimental and computational investigation of amido-thiourea promoted imine
hydrocyanation has revealed a new and unexpected mechanism of catalysis. Rather than …

Publisher Summary This chapter briefly reviews the use of deuterium to alter the metabolic
properties of compounds and discusses the past and current development of potential …

Halogen bonding is a recently rediscovered secondary interaction that shows potential to
become a complementary molecular tool to hydrogen bonding in rational drug design and in …

A detailed investigation of the influence of counterions on the [N–I–N]+ halogen bond in
solution, in the solid state and in silico is presented. Translational diffusion coefficients …

Cancer is one of the deadliest diseases in the world. In 2020, 19.3 million cancer cases and
10 million deaths were reported in the world. It is supposed that the prevalence of cancer …

Selective replacement of hydrogen atoms with deuterium (deuteration) has the unique
benefit of retaining the pharmacologic profile of physiologically active compounds while, in …

Owing to recent developments in tritium chemistry and analysis, high‐quality tritium‐labelled
drugs can now be prepared simply, cheaply and in timescales commensurate with those …