Mood disorders are common, chronic, recurrent mental illnesses that affect the lives of
millions of individuals worldwide. To date, the monoaminergic systems (serotonergic …

In the human brain,≈ 30% of the energy is spent on synaptic transmission. Disappearance
of synaptic activity is the earliest consequence of cerebral ischemia. The changes of …

To determine whether plasma lactate can be a significant fuel for human brain energy
metabolism, infusions of [3-13C] lactate and 1H-13C polarization transfer spectroscopy were …

Comparative neuroimaging can identify unique features of the human brain and teach us
about human brain evolution. Comparisons with chimpanzees, our closest living primate …

Continuous theta burst stimulation (cTBS) is a novel transcranial stimulation technique that
causes significant inhibition of synaptic transmission for≤ 1 h when applied over the primary …

Existing treatments for major depressive disorder (MDD) usually take weeks to months to
achieve their antidepressant effects, and a significant number of patients do not have …

Understanding the way in which plants develop, grow and interact with their environment
requires tools capable of a high degree of both spatial and temporal resolution. Magnetic …

▪ Abstract Magnetic resonance spectroscopy (MRS) has been used for more than two
decades to interrogate metabolite distributions in living cells and tissues. Techniques have …

Impaired glucose metabolism in the brain has been linked to several neurological disorders.
Positron emission tomography and carbon-13 magnetic resonance spectroscopic imaging …

In cerebral ischemia survival of neurons, astrocytes, oligodendrocytes and endothelial cells
is threatened during energy deprivation and/or following re-supply of oxygen and glucose …