Since the discovery of messenger RNA (mRNA), there have been tremendous efforts to
wield them in the development of therapeutics and vaccines. During the COVID-19 …

As the COVID-19 is still growing throughout the globe, a thorough investigation into the
specific immunopathology of SARS-CoV-2, its interaction with the host immune system and …

Humanity is currently facing the challenge of two devastating pandemics caused by two very
different RNA viruses: HIV-1, which has been with us for decades, and SARS-CoV-2, which …

Expression of the programmed death 1 (PD-1) receptor and its ligands are implicated in the
T cell exhaustion phenotype which contributes to the persistence of several chronic viral …

Hepatitis C is a pandemic human RNA virus, which commonly causes chronic infection and
liver disease. The characterization of viral populations that successfully initiate infection, and …

The development of a safe, effective and globally affordable HIV vaccine offers the best
hope for the future control of the HIV-1 pandemic. Since 1987, scores of candidate HIV-1 …

HIV-1 and its simian counterpart SIV have been exquisitely tailored by evolution to evade
host immunity. By virtue of specific adaptations that thwart individual innate or adaptive …

In the past decade, RNA therapeutics have gone from being a promising concept to one of
the most exciting frontiers in healthcare and pharmaceuticals. The field is now entering what …

The development of mouse/human chimeras through the engraftment of human immune
cells and tissues into immunodeficient mice, including the recently described humanized …

Study design Study RV254/SEARCH 010 is a prospective cohort study conducted in
Bangkok, Thailand, which enrols predominantly Thai participants in the earliest stages of …