Finding the genomic basis of local adaptation: pitfalls, practical solutions, and future directions
Uncovering the genetic and evolutionary basis of local adaptation is a major focus of
evolutionary biology. The recent development of cost-effective methods for obtaining high …
evolutionary biology. The recent development of cost-effective methods for obtaining high …
Bulk segregation analysis in the NGS era: a review of its teenage years
Z Li, Y Xu - The Plant Journal, 2022 - Wiley Online Library
Bulk segregation analysis (BSA) utilizes a strategy of pooling individuals with extreme
phenotypes to conduct economical and rapidly linked marker screening or quantitative trait …
phenotypes to conduct economical and rapidly linked marker screening or quantitative trait …
QTL‐seq: rapid mapping of quantitative trait loci in rice by whole genome resequencing of DNA from two bulked populations
The majority of agronomically important crop traits are quantitative, meaning that they are
controlled by multiple genes each with a small effect (quantitative trait loci, QTL s). Mapping …
controlled by multiple genes each with a small effect (quantitative trait loci, QTL s). Mapping …
Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1
A Amambua-Ngwa, KA Button-Simons, X Li… - Nature …, 2023 - nature.com
Malaria parasites break down host haemoglobin into peptides and amino acids in the
digestive vacuole for export to the parasite cytoplasm for growth: interrupting this process is …
digestive vacuole for export to the parasite cytoplasm for growth: interrupting this process is …
QTLseqr: An R package for bulk segregant analysis with next‐generation sequencing
BN Mansfeld, R Grumet - The plant genome, 2018 - Wiley Online Library
Next‐Generation Sequencing Bulk Segregant Analysis (NGS‐BSA) is efficient in detecting
quantitative trait loci (QTL). Despite the popularity of NGS‐BSA and the R statistical platform …
quantitative trait loci (QTL). Despite the popularity of NGS‐BSA and the R statistical platform …
Bulked sample analysis in genetics, genomics and crop improvement
Biological assay has been based on analysis of all individuals collected from sample
populations. Bulked sample analysis (BSA), which works with selected and pooled …
populations. Bulked sample analysis (BSA), which works with selected and pooled …
Next-generation sequencing accelerates crop gene discovery
The identification and isolation of genes underlying quantitative trait loci (QTLs) associated
with agronomic traits in crops have been recently accelerated thanks to next-generation …
with agronomic traits in crops have been recently accelerated thanks to next-generation …
Using next-generation sequencing to isolate mutant genes from forward genetic screens
K Schneeberger - Nature Reviews Genetics, 2014 - nature.com
The long-lasting success of forward genetic screens relies on the simple molecular basis of
the characterized phenotypes, which are typically caused by mutations in single genes …
the characterized phenotypes, which are typically caused by mutations in single genes …
Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations
The drivers and patterns of zoonotic virus emergence in the human population are poorly
understood. The mosquito Aedes aegypti is a major arbovirus vector native to Africa that …
understood. The mosquito Aedes aegypti is a major arbovirus vector native to Africa that …
Mapping QTLs for Salt Tolerance in Rice (Oryza sativa L.) by Bulked Segregant Analysis of Recombinant Inbred Lines Using 50K SNP Chip
Soil salinity is a major constraint to rice production in large inland and coastal areas around
the world. Modern high yielding rice varieties are particularly sensitive to high salt stress …
the world. Modern high yielding rice varieties are particularly sensitive to high salt stress …