Finding the genomic basis of local adaptation: pitfalls, practical solutions, and future directions

S Hoban, JL Kelley, KE Lotterhos… - The American …, 2016 - journals.uchicago.edu
Uncovering the genetic and evolutionary basis of local adaptation is a major focus of
evolutionary biology. The recent development of cost-effective methods for obtaining high …

Bulk segregation analysis in the NGS era: a review of its teenage years

Z Li, Y Xu - The Plant Journal, 2022 - Wiley Online Library
Bulk segregation analysis (BSA) utilizes a strategy of pooling individuals with extreme
phenotypes to conduct economical and rapidly linked marker screening or quantitative trait …

QTL‐seq: rapid mapping of quantitative trait loci in rice by whole genome resequencing of DNA from two bulked populations

H Takagi, A Abe, K Yoshida, S Kosugi… - The Plant …, 2013 - Wiley Online Library
The majority of agronomically important crop traits are quantitative, meaning that they are
controlled by multiple genes each with a small effect (quantitative trait loci, QTL s). Mapping …

Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1

A Amambua-Ngwa, KA Button-Simons, X Li… - Nature …, 2023 - nature.com
Malaria parasites break down host haemoglobin into peptides and amino acids in the
digestive vacuole for export to the parasite cytoplasm for growth: interrupting this process is …

QTLseqr: An R package for bulk segregant analysis with next‐generation sequencing

BN Mansfeld, R Grumet - The plant genome, 2018 - Wiley Online Library
Next‐Generation Sequencing Bulk Segregant Analysis (NGS‐BSA) is efficient in detecting
quantitative trait loci (QTL). Despite the popularity of NGS‐BSA and the R statistical platform …

Bulked sample analysis in genetics, genomics and crop improvement

C Zou, P Wang, Y Xu - Plant biotechnology journal, 2016 - Wiley Online Library
Biological assay has been based on analysis of all individuals collected from sample
populations. Bulked sample analysis (BSA), which works with selected and pooled …

Next-generation sequencing accelerates crop gene discovery

K Le Nguyen, A Grondin, B Courtois, P Gantet - Trends in plant science, 2019 - cell.com
The identification and isolation of genes underlying quantitative trait loci (QTLs) associated
with agronomic traits in crops have been recently accelerated thanks to next-generation …

Using next-generation sequencing to isolate mutant genes from forward genetic screens

K Schneeberger - Nature Reviews Genetics, 2014 - nature.com
The long-lasting success of forward genetic screens relies on the simple molecular basis of
the characterized phenotypes, which are typically caused by mutations in single genes …

Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations

F Aubry, S Dabo, C Manet, I Filipović, NH Rose… - Science, 2020 - science.org
The drivers and patterns of zoonotic virus emergence in the human population are poorly
understood. The mosquito Aedes aegypti is a major arbovirus vector native to Africa that …

Mapping QTLs for Salt Tolerance in Rice (Oryza sativa L.) by Bulked Segregant Analysis of Recombinant Inbred Lines Using 50K SNP Chip

S Tiwari, K Sl, V Kumar, B Singh, AR Rao, A Mithra SV… - PloS one, 2016 - journals.plos.org
Soil salinity is a major constraint to rice production in large inland and coastal areas around
the world. Modern high yielding rice varieties are particularly sensitive to high salt stress …