Abstract The interleukin 12 (IL-12) family is unique in having the only heterodimeric
cytokines, including IL-12, IL-23, IL-27 and IL-35. This feature endows these cytokines with a …

Abstract Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor
with many important functions in the biology of normal and transformed cells. Its regulation is …

Since their discovery as key mediators of cytokine signaling, considerable progress has
been made in defining the structure-function relationships of Signal Transducers and …

The signal transducers and activators of transcription (STAT) factors function as downstream
effectors of cytokine and growth factor receptor signaling. Compared with normal cells and …

Tyrosine phosphorylation regulates the dimerization of STATs as an essential prerequisite
for the establishment of a classical JAK-STAT signaling path. However, most vertebrate …

Constitutive activation of signal transducer and activator of transcription (STAT) proteins has
been detected in a wide variety of human primary tumor specimens and tumor cell lines …

Signal transducers and activators of transcription (STAT) proteins comprise a family of
transcription factors latent in the cytoplasm that participate in normal cellular events, such as …

Signal transducer and activator of transcription (STAT) proteins are a 7-member family of
cytoplasmic transcription factors that contribute to signal transduction by cytokines …

Prolific generation of NO by inducible nitric oxide synthase (iNOS) can cause unintended
injury to host cells during glomerulonephritis and other inflammatory diseases. While much …

Prolactin (PRL), a pituitary peptide hormone, is known to regulate diverse physiological
functions via its effects on cellular processes such as proliferation, differentiation, and cell …