Architecture of the dynamic fungal cell wall

NAR Gow, MD Lenardon - Nature Reviews Microbiology, 2023 - nature.com
The fungal cell wall is essential for growth and survival, and is a key target for antifungal
drugs and the immune system. The cell wall must be robust but flexible, protective and …

Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond

Y Lee, E Puumala, N Robbins, LE Cowen - Chemical reviews, 2020 - ACS Publications
Fungal infections are a major contributor to infectious disease-related deaths across the
globe. Candida species are among the most common causes of invasive mycotic disease …

The fungal cell wall: structure, biosynthesis, and function

NAR Gow, JP Latge, CA Munro - Microbiology spectrum, 2017 - Am Soc Microbiol
The molecular composition of the cell wall is critical for the biology and ecology of each
fungal species. Fungal walls are composed of matrix components that are embedded and …

Candida parapsilosis Virulence and Antifungal Resistance Mechanisms: A Comprehensive Review of Key Determinants

J Branco, IM Miranda, AG Rodrigues - Journal of Fungi, 2023 - mdpi.com
Candida parapsilosis is the second most common Candida species isolated in Asia,
Southern Europe, and Latin America and is often involved in invasive infections that …

Mechanisms of antifungal drug resistance

LE Cowen, D Sanglard… - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
Antifungal therapy is a central component of patient management for acute and chronic
mycoses. Yet, treatment choices are restricted because of the sparse number of antifungal …

Antifungal drug resistance among Candida species: mechanisms and clinical impact

M Sanguinetti, B Posteraro, C Lass‐Flörl - Mycoses, 2015 - Wiley Online Library
The epidemiology of Candida infections has changed in recent years. Although Candida
albicans is still the main cause of invasive candidiasis in most clinical settings, a substantial …

Echinocandin Resistance in Candida

DS Perlin - Clinical Infectious Diseases, 2015 - academic.oup.com
Invasive fungal infections are an important infection concern for patients with underlying
immunosuppression. Antifungal therapy is a critical component of patient care, but …

Candida albicans Antifungal Resistance and Tolerance in Bloodstream Infections: The Triad Yeast-Host-Antifungal

S Costa-de-Oliveira, AG Rodrigues - Microorganisms, 2020 - mdpi.com
Candida albicans represents the most frequent isolated yeast from bloodstream infections.
Despite the remarkable progress in diagnostic and therapeutic approaches, these infections …

Mechanisms of echinocandin antifungal drug resistance

DS Perlin - Annals of the new York Academy of Sciences, 2015 - Wiley Online Library
Fungal infections due to Candida and Aspergillus species cause extensive morbidity and
mortality, especially among immunosuppressed patients, and antifungal therapy is critical to …

Regulatory circuitry governing fungal development, drug resistance, and disease

RS Shapiro, N Robbins, LE Cowen - Microbiology and molecular …, 2011 - Am Soc Microbiol
Pathogenic fungi have become a leading cause of human mortality due to the increasing
frequency of fungal infections in immunocompromised populations and the limited …