MRSA infections: from classical treatment to suicide drugs

J Drebes, M Kunz, C Pereira, C Betzel… - Current Medicinal …, 2014 - ingentaconnect.com
Infections caused by the methicillin-resistant Staphylococcus aureus (MRSA) are today a
major burden in nosocomial disease control. The global trend shows an alarming increase …

Evaluation of the pharmacological descriptors related to the induction of antidepressant activity and its prediction by QSAR/QRAR methods

S Avram, C Buiu, D Duda-Seiman… - Mini Reviews in …, 2012 - ingentaconnect.com
Antidepressants are psychiatric agents used for the treatment of different types of
depression, being at present amongst the most commonly prescribed drugs, while their …

Advanced QSAR methods evaluated polycyclic aromatic compounds duality as drugs and inductors in psychiatric disorders

S Avram, M Mernea, D Mihailescu… - Current Organic …, 2013 - ingentaconnect.com
The central nervous system is endowed with complex mechanisms of defense. However,
these protection mechanisms fail in the presence of risk factors such as genetic mutations …

Distamycins: Strategies for possible enhancement of activity and specificity

R Cortesi, E Esposito - Mini reviews in medicinal chemistry, 2010 - ingentaconnect.com
The present review focused on the strategies aimed to possibly solve toxicity problems of
distamycins. Distamycins are compounds characterized by an oligopeptidic …

Prediction of improved antimicrobial mastoparan derivatives by 3D-QSAR-CoMSIA/CoMFA and computational mutagenesis

S Avram, D Mihailescu, F Borcan, AL Milac - Monatshefte für Chemie …, 2012 - Springer
Antimicrobial peptides are an important class of therapeutic agents used against a wide
range of pathogens such as gram-negative and-positive bacteria, fungi, and viruses. The …

Heterocyclic derivatives and use thereof

CH Park, SH Lee, J Im, SO Lee, J Kim, HK Park… - US Patent …, 2020 - Google Patents
This application is a National Stage of International et al., Nat. Rev. Mol. Cell Biol., 2002, 3).
Application No. PCT/KR2015/012926 filed Nov. 30, 2015, In particular, STAT3 protein is …

Opracowanie i charakterystyka elektrochemicznych genoczujników przeznaczonych do wykrywania wirusa ptasiej grypy typu H5N1

KD Malecka - 2016 - repozytorium.uwb.edu.pl
Przedmiotem niniejszej rozprawy było opracowanie czułych elektrochemicznych
genoczujników i zastosowanie ich do selektywnego wykrywania specyficznych sekwencji …

An investigation into nucleic acid binding compounds

F Scott - 2013 - stax.strath.ac.uk
Antibiotic reistance [sic] has become a major cause for concern in recent times and as such
there is increased demand for new drugs that can obviate this issue. The vast majority of …