Relevance of interactions between dopamine and glutamate neurotransmission in schizophrenia

SA Buck, M Quincy Erickson-Oberg, RW Logan… - Molecular …, 2022 - nature.com
Dopamine (DA) and glutamate neurotransmission are strongly implicated in schizophrenia
pathophysiology. While most studies focus on contributions of neurons that release only DA …

The heterogeneity of Parkinson's disease

U Wüllner, P Borghammer, C Choe, I Csoti… - Journal of Neural …, 2023 - Springer
The heterogeneity of Parkinson's disease (PD), ie the various clinical phenotypes,
pathological findings, genetic predispositions and probably also the various implicated …

Hormones and sex-specific medicine in human physiopathology

MR Tokatli, LG Sisti, E Marziali, L Nachira, MF Rossi… - Biomolecules, 2022 - mdpi.com
A prodigious increment of scientific evidence in both preclinical and clinical studies is
narrowing a major gap in knowledge regarding sex-specific biological responses observed …

Sex differences in dopaminergic vulnerability to environmental toxicants—implications for Parkinson's disease

A Adamson, SA Buck, Z Freyberg… - Current environmental …, 2022 - Springer
Abstract Purpose of Review Sex dimorphism in Parkinson's disease (PD) is an ostensible
feature of the neurological disorder, particularly as men are 1.5–2 times more likely to …

Roles of VGLUT2 and dopamine/glutamate co-transmission in selective vulnerability to dopamine neurodegeneration

SA Buck, MQ Erickson-Oberg, SH Bhatte… - ACS chemical …, 2022 - ACS Publications
Growing evidence has established that a subset of dopamine (DA) neurons co-release
glutamate and express vesicular glutamate transporter 2 (VGLUT2). VGLUT2 expression in …

Alterations in neurotransmitter co-release in Parkinson's disease

K Barcomb, CP Ford - Experimental Neurology, 2023 - Elsevier
Parkinson's disease is a neurological disorder characterized by degeneration of midbrain
dopamine neurons, which results in numerous adaptations in basal ganglia circuits …

Ventral pallidal GABAergic neuron calcium activity encodes cue-driven reward seeking and persists in the absence of reward delivery

A Scott, D Palmer, B Newell, I Lin… - Journal of …, 2023 - Soc Neuroscience
Reward-seeking behavior is often initiated by environmental cues that signal reward
availability. This is a necessary behavioral response; however, cue reactivity and reward …

A mini-review of the role of vesicular glutamate transporters in Parkinson's disease

C Zhao, C Wang, H Zhang, W Yan - Frontiers in Molecular …, 2023 - frontiersin.org
Parkinson's disease (PD) is a common neurodegenerative disease implicated in multiple
interacting neurotransmitter pathways. Glutamate is the central excitatory neurotransmitter in …

Transient MPTP exposure at a sensitive developmental window altered gut microbiome and led to male-biased motor and social behavioral deficits in adult zebrafish

H Dong, H Wu, C Bai, K Ye, L Mao, Y Lei, Y Liu, H Xu… - NeuroToxicology, 2022 - Elsevier
Zebrafish is an economical alternative model for developmental neurotoxicity (DNT) testing.
DNT studies in zebrafish have been focused on acute effects; few studies explore enduring …

Dopamine neurons exhibit emergent glutamatergic identity in Parkinson's disease

T Steinkellner, WS Conrad, I Kovacs, RA Rissman… - Brain, 2022 - academic.oup.com
Loss of midbrain dopamine neurons causes the cardinal symptoms of Parkinson's disease.
However, not all dopamine neurons are equally vulnerable and a better understanding of …