[HTML][HTML] The ACE2/angiotensin-(1–7)/MAS axis of the renin-angiotensin system: focus on angiotensin-(1–7)

RAS Santos, WO Sampaio, AC Alzamora… - Physiological …, 2017 - journals.physiology.org
The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular
system and hydroelectrolyte balance, with an influence on organs and functions throughout …

The anti-inflammatory potential of ACE2/angiotensin-(1-7)/Mas receptor axis: evidence from basic and clinical research

TR Rodrigues Prestes, NP Rocha… - Current drug …, 2017 - ingentaconnect.com
Background: The renin angiotensin system (RAS) plays an important role in inflammation
and fibrosis. The classical axis of the RAS, formed by angiotensin converting en-zyme …

[HTML][HTML] Angiotensin-converting enzyme 2 and angiotensin 1–7: novel therapeutic targets

F Jiang, J Yang, Y Zhang, M Dong, S Wang… - Nature Reviews …, 2014 - nature.com
The renin–angiotensin system (RAS) has pivotal roles in the regulation of normal physiology
and the pathogenesis of cardiovascular disease. Angiotensin-converting enzyme (ACE) 2 …

ACE2, angiotensin‐(1‐7) and M as receptor axis in inflammation and fibrosis

AC Simões e Silva, KD Silveira… - British journal of …, 2013 - Wiley Online Library
Recent advances have improved our understanding of the renin‐angiotensin system (RAS).
These have included the recognition that angiotensin (A ng)‐(1‐7) is a biologically active …

[HTML][HTML] ACE2 in the era of SARS-CoV-2: controversies and novel perspectives

F Saponaro, G Rutigliano, S Sestito… - Frontiers in Molecular …, 2020 - frontiersin.org
Angiotensin-converting enzyme 2 (ACE2) is related to ACE but turned out to counteract
several pathophysiological actions of ACE. ACE2 exerts antihypertensive and …

ACE inhibition, ACE2 and angiotensin-(1⿿ 7) axis in kidney and cardiac inflammation and fibrosis

ACS e Silva, MM Teixeira - Pharmacological research, 2016 - Elsevier
Abstract The Renin Angiotensin System (RAS) is a pivotal physiological regulator of heart
and kidney homeostasis, but also plays an important role in the pathophysiology of heart …

International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin receptors: interpreters of pathophysiological angiotensinergic stimuli

SS Karnik, H Unal, JR Kemp, KC Tirupula… - Pharmacological …, 2015 - ASPET
The renin angiotensin system (RAS) produced hormone peptides regulate many vital body
functions. Dysfunctional signaling by receptors for RAS peptides leads to pathologic states …

[HTML][HTML] Diabetic nephropathy: novel molecular mechanisms and therapeutic targets

C Zoja, C Xinaris, D Macconi - Frontiers in pharmacology, 2020 - frontiersin.org
Diabetic nephropathy (DN) is one of the major microvascular complications of diabetes
mellitus and the leading cause of end-stage kidney disease. The standard treatments for …

Mas and its related G protein–coupled receptors, Mrgprs

M Bader, N Alenina, MA Andrade-Navarro… - Pharmacological …, 2014 - ASPET
The Mas-related G protein–coupled receptors (Mrgprs or Mas-related genes) comprise a
subfamily of receptors named after the first discovered member, Mas. For most Mrgprs …

ACE and ACE2 in inflammation: a tale of two enzymes

R Reddy Gaddam, S Chambers… - Inflammation & Allergy …, 2014 - ingentaconnect.com
The renin-angiotensin system (RAS) conceived as a coordinated hormonal cascade plays
an important role in controlling multiple functions in many organs and is much more complex …