Oocytes are sequestered in primordial follicles before birth and remain quiescent in the
ovary, often for decades, until recruited into the growing pool throughout the reproductive …

A now large body of evidence supports the existence of mitotically active germ cells in
postnatal ovaries of diverse mammalian species, including humans. This opens the …

MicroRNAs (miRs) play a key role in the control of gene expression in a wide array of tissue
systems, where their functions include the regulation of self-renewal, cellular differentiation …

Purpose Although early menopause frequently occurs in female cancer patients after
chemotherapy (CTx), bone marrow (BM) transplantation (BMT) has been linked to an …

Of all the major organ systems in the body, the ovaries of females are the first to exhibit
impaired function with advancing age. Until recently, traditional thinking was that female …

Age‐related ovarian failure in women heralds the transition into postmenopausal life, which
is characterized by a loss of fertility and increased risk for cardiovascular disease …

Objective The goal of this study was to determine whether mutations of meiotic genes, such
as disrupted meiotic cDNA (DMC1), MutS homolog (MSH4), MSH5, and S. cerevisiae …

Reports indicate that germ-line stem cells present in adult mice can rapidly generate new
oocytes and contribute to the primordial follicle reserve following conditions of ovotoxic …

Whether or not oogenesis continues in the ovaries of mammalian females during postnatal
life was heavily debated from the late 1800s through the mid-1900s. However, in 1951 Lord …

The regulation of pig theca cell steroidogenesis was studied by the development of a
physiological serum-free culture system, which was subsequently extended to investigate …