Antioxidants and antioxidant methods: An updated overview

İ Gulcin - Archives of toxicology, 2020 - Springer
Antioxidants had a growing interest owing to their protective roles in food and
pharmaceutical products against oxidative deterioration and in the body and against …

Discovery of novel benzenesulfonamides incorporating 1, 2, 3-triazole scaffold as carbonic anhydrase I, II, IX, and XII inhibitors

A Buza, C Türkeş, M Arslan, Y Demir, B Dincer… - International Journal of …, 2023 - Elsevier
Sulfonamides are among the most promising potential inhibitors for carbonic anhydrases
(CAs), which are pharmaceutically relevant targets for treating several disease conditions …

Carbonic anhydrase inhibitors from marine natural products

CT Supuran - Marine Drugs, 2022 - mdpi.com
Carbonic anhydrases (CAs, EC 4.2. 1.1) are widespread metalloenzymes in organisms in all
life kingdoms, being involved in pH regulation, metabolic processes and many other …

[HTML][HTML] Synthesis and inhibition profiles of N-benzyl-and N-allyl aniline derivatives against carbonic anhydrase and acetylcholinesterase–A molecular docking study

I Mahmudov, Y Demir, Y Sert, Y Abdullayev… - Arabian Journal of …, 2022 - Elsevier
The alkyl and aryl derivatives of aniline are important starting materials in fine organic
synthesis. Allyl bromide and benzyl chloride were taken as substrates for the alkylation …

Antidiabetic and antiparasitic potentials: Inhibition effects of some natural antioxidant compounds on α-glycosidase, α-amylase and human glutathione S-transferase …

İ Gulçin, P Taslimi, A Aygün, N Sadeghian… - International journal of …, 2018 - Elsevier
The glutathione S-transferase (GST) was purified from fresh blood erythrocytes using affinity
column chromatography. Also, α-amylase from porcine pancreas and α-glycosidase from …

Synthesis, characterization, inhibition effects, and molecular docking studies as acetylcholinesterase, α-glycosidase, and carbonic anhydrase inhibitors of novel …

N Lolak, S Akocak, C Türkeş, P Taslimi, M Işık… - Bioorganic …, 2020 - Elsevier
Some metabolic enzyme inhibitors can be used in the treatment of many diseases.
Therefore, synthesis and determination of alternative inhibitors are essential. In this study …

Isofraxidin: Antioxidant, Anti‐carbonic Anhydrase, Anti‐cholinesterase, Anti‐diabetic, and in Silico Properties

L Durmaz, İ Gulçin, P Taslimi, B Tüzün - ChemistrySelect, 2023 - Wiley Online Library
The development of innovative pharmacological formulations for the treatment and
prevention of various major diseases, including cancer, diabetes, and glaucoma, has been …

Investigation of inhibitory properties of some hydrazone compounds on hCA I, hCA II and AChE enzymes

K Kucukoglu, HI Gul, P Taslimi, I Gulcin… - Bioorganic chemistry, 2019 - Elsevier
Recently, inhibition of carbonic anhydrase (hCA) and acetylcholinesterase (AChE) have
appeared as a promising approach for pharmacological intervention in a variety of disorders …

The first synthesis, carbonic anhydrase inhibition and anticholinergic activities of some bromophenol derivatives with S including natural products

C Bayrak, P Taslimi, HS Karaman, I Gulcin… - Bioorganic chemistry, 2019 - Elsevier
Starting from vanillin, known four benzyl bromides with Br were synthesized. The first
synthesis of natural product 3, 4-dibromo-5-((methylsulfonyl) methyl) benzene-1, 2-diol (2) …

Synthesis of nitrogen, phosphorus, selenium and sulfur-containing heterocyclic compounds–determination of their carbonic anhydrase, acetylcholinesterase …

İ Gülçin, B Trofimov, R Kaya, P Taslimi, L Sobenina… - Bioorganic …, 2020 - Elsevier
Abstract Sulfur-containing pyrroles (1–3), tris (2-pyridyl) phosphine (selenide) sulfide (4–5)
and 4-benzyl-6-(thiophen-2-yl) pyrimidin-2-amine (6) were synthesized and characterized …