The initiation of eukaryotic DNA replication
A Costa, JFX Diffley - Annual review of biochemistry, 2022 - annualreviews.org
DNA replication in eukaryotic cells initiates from large numbers of sites called replication
origins. Initiation of replication from these origins must be tightly controlled to ensure the …
origins. Initiation of replication from these origins must be tightly controlled to ensure the …
Origins of DNA replication in eukaryotes
Y Hu, B Stillman - Molecular cell, 2023 - cell.com
Errors occurring during DNA replication can result in inaccurate replication, incomplete
replication, or re-replication, resulting in genome instability that can lead to diseases such as …
replication, or re-replication, resulting in genome instability that can lead to diseases such as …
Mechanisms of chromatin-based epigenetic inheritance
Multi-cellular organisms such as humans contain hundreds of cell types that share the same
genetic information (DNA sequences), and yet have different cellular traits and functions …
genetic information (DNA sequences), and yet have different cellular traits and functions …
MAVE-NN: learning genotype-phenotype maps from multiplex assays of variant effect
Multiplex assays of variant effect (MAVEs) are a family of methods that includes deep
mutational scanning experiments on proteins and massively parallel reporter assays on …
mutational scanning experiments on proteins and massively parallel reporter assays on …
The structure of ORC–Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6
X Feng, Y Noguchi, M Barbon, B Stillman… - Nature …, 2021 - nature.com
Abstract The Origin Recognition Complex (ORC) binds to sites in chromosomes to specify
the location of origins of DNA replication. The S. cerevisiae ORC binds to specific DNA …
the location of origins of DNA replication. The S. cerevisiae ORC binds to specific DNA …
[HTML][HTML] Mobile origin-licensing factors confer resistance to conflicts with RNA polymerase
Fundamental to our understanding of chromosome duplication is the idea that replication
origins function both as sites where MCM helicases are loaded during the G1 phase and …
origins function both as sites where MCM helicases are loaded during the G1 phase and …
Nucleosome-directed replication origin licensing independent of a consensus DNA sequence
The numerous enzymes and cofactors involved in eukaryotic DNA replication are conserved
from yeast to human, and the budding yeast Saccharomyces cerevisiae (Sc) has been a …
from yeast to human, and the budding yeast Saccharomyces cerevisiae (Sc) has been a …
The dynamic nature of the human origin recognition complex revealed through five cryoEM structures
Genome replication is initiated from specific origin sites established by dynamic events. The
Origin Recognition Complex (ORC) is necessary for orchestrating the initiation process by …
Origin Recognition Complex (ORC) is necessary for orchestrating the initiation process by …
The human origin recognition complex is essential for pre-RC assembly, mitosis, and maintenance of nuclear structure
HC Chou, K Bhalla, OEL Demerdesh, O Klingbeil… - Elife, 2021 - elifesciences.org
The origin recognition complex (ORC) cooperates with CDC6, MCM2-7, and CDT1 to form
pre-RC complexes at origins of DNA replication. Here, using tiling-sgRNA CRISPR screens …
pre-RC complexes at origins of DNA replication. Here, using tiling-sgRNA CRISPR screens …
Transcriptional activity of the bacterial replication initiator DnaA
IP Menikpurage, K Woo, PE Mera - Frontiers in microbiology, 2021 - frontiersin.org
In bacteria, DnaA is the most conserved DNA replication initiator protein. DnaA is a DNA
binding protein that is part of the AAA+ ATPase family. In addition to initiating chromosome …
binding protein that is part of the AAA+ ATPase family. In addition to initiating chromosome …