Significance: Reactive oxygen species (ROS) are generated by exogenous and
environmental genotoxins, but also arise from mitochondria as byproducts of respiration in …

Guanine oxidation occurs in both DNA and the cellular nucleotide pool, and one of the major
products is 8-hydroxyguanine (8-oxo-7, 8-dihydroguanine). The mutagenic potentials of this …

8-Oxoguanine (8-oxoG) is a major oxidative lesion produced in DNA by normal cellular
metabolism or after exposure to exogenous sources such as ionizing radiation. Persistence …

DNA damage incurred by a multitude of endogenous and exogenous factors constitutes an
inevitable challenge for the replication machinery. Cells rely on various mechanisms to …

Adducts arise from the chemical modification of bases in DNA or amino acids in proteins by
toxic chemicals. Many chemicals known to be carcinogenic in humans have been shown to …

To appreciate the nature of this subject, it is useful to first consider the general topic of
chemical carcinogenesis. In a sense the field began with the observations of two London …

7, 8-Dihydro-8-oxoguanine (oxoG) is the most abundant oxidative DNA lesion with dual
coding properties. It forms both Watson–Crick (anti) oxoG:(anti) C and Hoogsteen (syn) …

Using an established high-performance liquid chromatography (HPLC) method based on
anion exchange chromatography, fraction collection, and electrochemical detection, the …

To clarify the role of 8‐OHdG formation as a starting point for carcinogenesis, we examined
the dose‐dependence and time‐course of changes of OGG1 mRNA expression, 8‐OHdG …

The formation of 8-hydroxyguanine (8-OH-Gua, 7, 8-dihydro-8-oxoguanine) in DNA and in
the nucleotide pool results in G: C→ T: A and A: T→ C: G substitution mutations …