Decades of research have mapped out the basic mechanics of the Hippo pathway. The
paralogues Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding …

Combined therapeutic strategies hold promises in augmenting antigen release to enhance
anti-tumor immunity, which have garnered attention in numerous scholarly reviews. Beyond …

Cancer stem cells (CSCs) within protumorigenic microlesions are a critical driver in the
initiation and progression of early stage lung cancer, where immune cells provide an …

Background Epithelial-to-mesenchymal transition (EMT) and cancer stem-like cells (CSLCs)
play crucial role in tumor metastasis and drug-resistance. Disheveled3 (DVL3) is involved in …

Hippo pathway plays a crucial role in the progression of hepatocellular carcinoma (HCC),
and yes-associated protein (YAP) is one of the major factors of the Hippo pathway. However …

Although obesity contributes to tumor incidence and progression in various cancers,
whether obesity impacts the tumor microenvironment (TME) of non-small cell lung cancer …

Hepatocellular carcinoma (HCC) is a lethal disease with limited management strategies and
poor prognosis. Metabolism alternations have been frequently unveiled in HCC, including …

The current review elucidates the characteristics and related regulating pathways of lung
CSCs from essential to preclinical research. We retrospectively introduce an update on the …

Hepatocellular carcinoma (HCC) acquires an immunosuppressive microenvironment,
leading to unbeneficial therapeutic outcomes. Hyaluronan-mediated motility receptor …

Hippo pathway has been initially recognized as a regulatory mechanism for modulation of
organ size in fruitfly. Subsequently, its involvement in the regulation of homeostasis and …