Regulatory role of Sirtuin 1 (SIRT1), one of the most extensively studied members of its kind
in histone deacetylase family in governing multiple cellular fates, is predominantly linked to …

The p53 protein is mutated in about 50% of human cancers. Aside from losing the tumor-
suppressive functions of the wild-type form, mutant p53 proteins often acquire inherent …

Inactivation of the p53 tumor suppressor is a frequent event in tumorigenesis. In most cases,
the p53 gene is mutated, giving rise to a stable mutant protein whose accumulation is …

Reactive oxygen species (ROS) and their products are components of cell signaling
pathways and play important roles in cellular physiology and pathophysiology. Under …

Abstract p53 is the major tumor suppressor and the most frequently inactivated gene in
cancer. p53 could be disabled either by mutations or by upstream negative regulators …

Abstract Viruses cause 10–15% of all human cancers. Massively parallel sequencing has
recently proved effective for uncovering novel viruses and virus–tumour associations, but …

In vitro modeling of human disease has recently become feasible with induced pluripotent
stem cell (iPSC) technology. Here, we established patient-derived iPSCs from a Li-Fraumeni …

Rare hereditary disorders provide unequivocal evidence of the importance of genes in
human disease pathogenesis. Familial syndromes that predispose to osteosarcomagenesis …

Most human cancers harbor mutations in the gene encoding p53. As a result, research on
p53 in the past few decades has focused primarily on its role as a tumor suppressor. One …

Senescence is a cellular state which involves cell cycle arrest and a proinflammatory
phenotype, and it has traditionally been associated with cellular and organismal aging …