Gastrointestinal neuroendocrine tumors: pancreatic endocrine tumors

DC Metz, RT Jensen - Gastroenterology, 2008 - Elsevier
Pancreatic endocrine tumors (PETs) have long fascinated clinicians and investigators
despite their relative rarity. Their clinical presentation varies depending on whether the …

The diagnosis and medical management of advanced neuroendocrine tumors

GA Kaltsas, GM Besser, AB Grossman - Endocrine reviews, 2004 - academic.oup.com
Neuroendocrine tumors (NETs) constitute a heterogeneous group of neoplasms that
originate from endocrine glands such as the pituitary, the parathyroids, and the …

The management of insulinoma

ON Tucker, PL Crotty, KC Conlon - Journal of British Surgery, 2006 - academic.oup.com
Background Insulinomas are rare tumours. Their clinical presentation, localization
techniques and operative management were reviewed. Methods An electronic search of the …

Targeting the epidermal growth factor receptor by gefitinib for treatment of hepatocellular carcinoma

M Höpfner, AP Sutter, A Huether, D Schuppan… - Journal of …, 2004 - Elsevier
BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) is one of the most common cancer-
related causes of death worldwide. Due to very poor 5-year-survival new therapeutic …

[HTML][HTML] PI3K-AKT-mTOR-signaling and beyond: the complex network in gastroenteropancreatic neuroendocrine neoplasms

F Briest, P Grabowski - Theranostics, 2014 - ncbi.nlm.nih.gov
Gastroenteropancreatic neuroendocrine neoplasms are heterogeneous in their clinical
behavior and require therapies specially tailored according to staging, grading, origin and …

Recent advances on the molecular mechanisms involved in pancreatic cancer progression and therapies

M Mimeault, RE Brand, AA Sasson, SK Batra - Pancreas, 2005 - journals.lww.com
This review describes the recent advances in the molecular events involved in pancreatic
cancer initiation, progression, and metastasis. Additionally, the importance of deregulated …

Blockade of IGF-1 receptor tyrosine kinase has antineoplastic effects in hepatocellular carcinoma cells

M Höpfner, A Huether, AP Sutter, V Baradari… - Biochemical …, 2006 - Elsevier
Hepatocellular carcinoma (HCC) is one of the most common cancer-related causes of death
worldwide. Due to very poor 5-year-survival new therapeutic approaches are mandatory …

Chemotherapy for advanced non-pancreatic well-differentiated neuroendocrine tumours of the gastrointestinal tract, a systematic review and meta-analysis: A lost …

A Lamarca, E Elliott, J Barriuso, A Backen… - Cancer Treatment …, 2016 - Elsevier
Background Chemotherapy is well-established in the treatment of patients with well-
differentiated neuroendocrine tumours (NETs) arising from the pancreas (pNETs); however …

Epidermal growth factor receptor and activated epidermal growth factor receptor expression in gastrointestinal carcinoids and pancreatic endocrine carcinomas

B Papouchado, LA Erickson, AL Rohlinger… - Modern …, 2005 - nature.com
The epidermal growth factor receptor (EGFR) plays an important role in the pathogenesis of
many tumors. To analyze the expression of EGFR and activated EGFR in well-differentiated …

The insulin-like growth factor receptor 1 is a promising target for novel treatment approaches in neuroendocrine gastrointestinal tumours

M Hopfner, V Baradari, A Huether… - Endocrine-Related …, 2006 - erc.bioscientifica.com
Gastrointestinal neuroendocrine tumours (NET) represent a heterogeneous tumour entity.
The anti-neoplastic therapy of advanced NET disease is still unsatisfactory and innovative …