Long-term consequences of traumatic brain injury: current status of potential mechanisms of injury and neurological outcomes

HM Bramlett, WD Dietrich - Journal of neurotrauma, 2015 - liebertpub.com
Traumatic brain injury (TBI) is a significant clinical problem with few therapeutic interventions
successfully translated to the clinic. Increased importance on the progressive, long-term …

[HTML][HTML] Biomarkers for the diagnosis, prognosis, and evaluation of treatment efficacy for traumatic brain injury

PK Dash, J Zhao, G Hergenroeder, AN Moore - Neurotherapeutics, 2010 - Elsevier
Traumatic brain injury (TBI) remains a serious health concern, and TBI is one of the leading
causes of death and disability, especially among young adults. Although preventive …

Human traumatic brain injury induces autoantibody response against glial fibrillary acidic protein and its breakdown products

Z Zhang, JS Zoltewicz, S Mondello, KJ Newsom… - PloS one, 2014 - journals.plos.org
The role of systemic autoimmunity in human traumatic brain injury (TBI) and other forms of
brain injuries is recognized but not well understood. In this study, a systematic investigation …

Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation

AH Hawasli, DR Benavides, C Nguyen, JW Kansy… - Nature …, 2007 - nature.com
Learning is accompanied by modulation of postsynaptic signal transduction pathways in
neurons. Although the neuronal protein kinase cyclin-dependent kinase 5 (Cdk5) has been …

Calpain as a therapeutic target in traumatic brain injury

KE Saatman, J Creed, R Raghupathi - Neurotherapeutics, 2010 - Springer
The family of calcium-activated neutral proteases, calpains, appears to play a key role in
neuropathologic events following traumatic brain injury (TBI). Neuronal calpain activation …

Blood-based diagnostics of traumatic brain injuries

S Mondello, U Muller, A Jeromin, J Streeter… - Expert review of …, 2011 - Taylor & Francis
Traumatic brain injury is a major health and socioeconomic problem that affects all societies.
However, traditional approaches to the classification of clinical severity are the subject of …

A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome

S Lu, K Kanekura, T Hara… - Proceedings of the …, 2014 - National Acad Sciences
Wolfram syndrome is a genetic disorder characterized by diabetes and neurodegeneration
and considered as an endoplasmic reticulum (ER) disease. Despite the underlying …

Current status of fluid biomarkers in mild traumatic brain injury

JR Kulbe, JW Geddes - Experimental neurology, 2016 - Elsevier
Mild traumatic brain injury (mTBI) affects millions of people annually and is difficult to
diagnose. Mild injury is insensitive to conventional imaging techniques and diagnoses are …

Serum brain biomarker level, neurocognitive performance, and self-reported symptom changes in soldiers repeatedly exposed to low-level blast: a breacher pilot …

CM Tate, KKW Wang, S Eonta, Y Zhang… - Journal of …, 2013 - liebertpub.com
Abstract “Breachers” are a unique military and law enforcement population because they are
routinely exposed to low-level blast (LLB) during training and operations. This repeated …

Chronic neurodegenerative consequences of traumatic brain injury

NB Chauhan - Restorative neurology and neuroscience, 2014 - content.iospress.com
Traumatic brain injury (TBI) is a serious public health concern and a major cause of death
and disability worldwide. Each year, an estimated 1.7 million Americans sustain TBI of …