Alcoholic liver disease

HK Seitz, R Bataller, H Cortez-Pinto, B Gao… - Nature reviews Disease …, 2018 - nature.com
Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease worldwide.
ALD can progress from alcoholic fatty liver (AFL) to alcoholic steatohepatitis (ASH), which is …

[HTML][HTML] Alcohol-related liver disease: basic mechanisms and clinical perspectives

SY Liu, IT Tsai, YC Hsu - International journal of molecular sciences, 2021 - mdpi.com
Alcohol-related liver disease (ALD) refers to the liver damage occurring due to excessive
alcohol consumption and involves a broad spectrum of diseases that includes liver steatosis …

[HTML][HTML] miRNA signature in NAFLD: a turning point for a non-invasive diagnosis

P Dongiovanni, M Meroni, M Longo, S Fargion… - International journal of …, 2018 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) defines a wide pathological spectrum ranging from
simple steatosis to nonalcoholic steatohepatitis (NASH) which may predispose to liver …

[HTML][HTML] Role of microRNAs in alcohol-induced liver disorders and non-alcoholic fatty liver disease

JL Torres, I Novo-Veleiro, L Manzanedo… - World journal of …, 2018 - ncbi.nlm.nih.gov
MicroRNAs (miRNAs) are small non-coding RNAs that regulate multiple physiological and
pathological functions through the modulation of gene expression at the post-transcriptional …

MicroRNA 122, regulated by GRLH2, protects livers of mice and patients from ethanol-induced liver disease

A Satishchandran, A Ambade, S Rao, YC Hsueh… - Gastroenterology, 2018 - Elsevier
Background & Aims Chronic, excessive alcohol consumption leads to alcoholic liver disease
(ALD) characterized by steatosis, inflammation, and eventually cirrhosis. The hepatocyte …

[HTML][HTML] Genetic and epigenetic modifiers of alcoholic liver disease

M Meroni, M Longo, R Rametta… - International journal of …, 2018 - mdpi.com
Alcoholic liver disease (ALD), a disorder caused by excessive alcohol consumption is a
global health issue. More than two billion people consume alcohol in the world and about 75 …

[HTML][HTML] Immunotherapy for targeting cancer stem cells in hepatocellular carcinoma

X Dai, Y Guo, Y Hu, X Bao, X Zhu, Q Fu, H Zhang… - Theranostics, 2021 - ncbi.nlm.nih.gov
The rapid development and remarkable success of checkpoint inhibitors have provided
significant breakthroughs in cancer treatment, including hepatocellular carcinoma (HCC) …

Alcohol and hepatocellular carcinoma

H Matsushita, A Takaki - BMJ open gastroenterology, 2019 - bmjopengastro.bmj.com
Background Alcohol is classified as a Group 1 carcinogen by the International Agency for
Research on Cancer because it induces hepatocellular carcinoma (among other cancers) in …

[HTML][HTML] Alcohol-related changes in the intestinal microbiome influence neutrophil infiltration, inflammation and steatosis in early alcoholic hepatitis in mice

PP Lowe, B Gyongyosi, A Satishchandran… - PloS one, 2017 - journals.plos.org
Background Alcohol-induced intestinal dysbiosis disrupts homeostatic gut-liver axis function
and is essential in the development of alcoholic liver disease. Here, we investigate changes …

[HTML][HTML] Long noncoding RNA MEG3 suppresses liver cancer cells growth through inhibiting β-catenin by activating PKM2 and inactivating PTEN

Q Zheng, Z Lin, J Xu, Y Lu, Q Meng, C Wang… - Cell Death & …, 2018 - nature.com
Abstract Maternally expressed gene 3 (MEG3) encodes an lncRNA which is suggested to
function as a tumor suppressor and has been showed to involve in a variety of cancers …