Peripheral nerve sheath tumors are common neoplasms, with classic identifiable features,
but on occasion, they are diagnostically challenging. Although well-defined subtypes of …

Abstract p16 Ink4a is a protein involved in regulation of the cell cycle. Currently, p16 Ink4a is
considered a tumor suppressor protein because of its physiological role and downregulated …

Malignant peripheral nerve sheath tumors (MPNSTs) represent a group of highly aggressive
soft-tissue sarcomas that may occur sporadically, in association with neurofibromatosis type …

Pathology and Genetics of Head and Neck Tumoursis the latest volume in the new WHO
series, on histological and genetic typing of human tumours. This authoritative, concise …

Here's your ideal reference on the diagnosis of tumors of the skeletal muscles, connective
tissue, fat, and related structures. No other textbook matches its scope and depth of …

(Hughes, 1994). Consistent with its role as a classical tumor suppressor gene, loss of
heterozygosity (LOH) or Introduction“second-hit” somatic mutations in the inherited wild …

Summary Patients with neurofibromatosis 1 (NF1) develop multiple neurofibromas, with 8%
to 15% of patients experiencing malignant peripheral nerve sheath tumor (MPNST) during …

The RAS pathway is one of the most commonly deregulated pathways in human cancer.
Mutations in RAS genes occur in nearly 30% of all human tumors. However in some tumor …

Benign peripheral nerve sheath tumors (PNSTs) are a characteristic feature of
neurofibromatosis type I (NF1) patients. NF1 individuals have an 8–13% lifetime risk of …

There are no effective therapies for many tumours of the nervous system. This is, in part, a
consequence of their location within relatively inaccessible tissues. It is also likely, however …