[HTML][HTML] Mechanism of cell death pathways in status epilepticus and related therapeutic agents

K Du, M He, D Zhao, Y Wang, C Ma, H Liang… - Biomedicine & …, 2022 - Elsevier
The most severe form of epilepsy, status epilepticus (SE), causes brain damage and results
in the development of recurring seizures. Currently, the management of SE remains a …

Astrocyte-derived SerpinA3N promotes neuroinflammation and epileptic seizures by activating the NF-κB signaling pathway in mice with temporal lobe epilepsy

C Liu, XM Zhao, Q Wang, TT Du, MX Zhang… - Journal of …, 2023 - Springer
Impaired activation and regulation of the extinction of inflammatory cells and molecules in
injured neuronal tissues are key factors in the development of epilepsy. SerpinA3N is mainly …

Epilepsy in the Renaissance: a survey of remedies from 16th and 17th century German herbals

M Adams, SV Schneider, M Kluge, M Kessler… - Journal of …, 2012 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: Before modern anticonvulsive drugs were
developed people in central Europe used herbal remedies to treat epilepsy. Hundreds of …

Tipping the scales: Lessons from simple model systems on inositol imbalance in neurological disorders

AD Frej, GP Otto, RSB Williams - European journal of cell biology, 2017 - Elsevier
Inositol and inositol-containing compounds have signalling and regulatory roles in many
cellular processes, suggesting that inositol imbalance may lead to wide-ranging changes in …

The potential role of leucine-rich repeat-containing protein 8A in central nervous system: current situation and prospect

Z Wang, Y Li, Z Zeng, S Guo, W Chen, Y Luo - Neuroscience, 2022 - Elsevier
Cell swelling usually initiates the regulatory volume decrease (RVD) process mediated
mainly by volume-regulated anion channels (VRACs), which are formed by multiple different …

Brain tumour-associated status epilepticus

J Goonawardena, LAG Marshman… - Journal of Clinical …, 2015 - Elsevier
We have reviewed the scant literature on status epilepticus in patients with brain tumours.
Patients with brain tumour-associated epilepsy (TAE) appear less likely to develop status …

Intrastrain differences in seizure susceptibility, pharmacological response and basal neurochemistry of Wistar rats

J Portelli, N Aourz, D De Bundel, A Meurs, I Smolders… - Epilepsy research, 2009 - Elsevier
Reliable well-characterised animal models of seizures are necessary in order to better
understand the underlying pathophysiological mechanisms as well as to screen potential …

Long‐term effects of myoinositol on behavioural seizures and biochemical changes evoked by kainic acid induced epileptogenesis

L Tsverava, M Kandashvili… - Biomed Research …, 2019 - Wiley Online Library
Epilepsy is one of the most devastating neurological diseases and despite significant efforts
there is no cure available. Occurrence of spontaneous seizures in epilepsy is preceded by …

The protective effect of myo-inositol on hippocamal cell loss and structural alterations in neurons and synapses triggered by kainic acid-induced status epilepticus

N Kotaria, M Kiladze, MG Zhvania, NJ Japaridze… - Cellular and molecular …, 2013 - Springer
It is known that myo-inositol pretreatment attenuates the seizure severity and several
biochemical changes provoked by experimentally induced status epilepticus. However, it …

Hippocampal betaine/GABA transporter mRNA expression is not regulated by inflammation or dehydration post‐status epilepticus

NM Rowley, MD Smith, JG Lamb… - Journal of …, 2011 - Wiley Online Library
J. Neurochem.(2011) 117, 82–90. Abstract Seizure activity can alter GABA transporter and
osmoprotective gene expression, which may be involved in the pathogenesis of epilepsy …