Novel In Silico mRNA vaccine design exploiting proteins of M. tuberculosis that modulates host immune responses by inducing epigenetic modifications

H Al Tbeishat - Scientific Reports, 2022 - nature.com
Tuberculosis is an airborne infectious disease caused by Mycobacterium tuberculosis. BCG
is the only approved vaccine. However, it has limited global efficacy. Pathogens could affect …

The inter-talk between Mycobacterium tuberculosis and the epigenetic mechanisms

S Tarashi, SA Badi, A Moshiri, N Ebrahimzadeh… - …, 2020 - Taylor & Francis
Epigenetics regulate gene function without any alteration in the DNA sequence. The
epigenetics represent one of the most important regulators in different cellular processes …

Development of new preventive and therapeutic vaccines for tuberculosis

BE Kwon, JH Ahn, S Min, H Kim, J Seo… - Immune …, 2018 - synapse.koreamed.org
Tuberculosis (TB) is a contagious disease that has been responsible for the death of one
billion people in the last 200 years. Until now, the only vaccine approved for the prevention …

Mycobacterium tuberculosis Modulates miR-106b-5p to Control Cathepsin S Expression Resulting in Higher Pathogen Survival and Poor T-Cell Activation

D Pires, EM Bernard, JP Pombo, N Carmo… - Frontiers in …, 2017 - frontiersin.org
The success of tuberculosis (TB) bacillus, Mycobacterium tuberculosis (Mtb), relies on the
ability to survive in host cells and escape to immune surveillance and activation. We recently …

An autophagy-inducing and TLR-2 activating BCG vaccine induces a robust protection against tuberculosis in mice

A Khan, P Bakhru, S Saikolappan, K Das, E Soudani… - npj Vaccines, 2019 - nature.com
Mycobacterium bovis BCG is widely used as a vaccine against tuberculosis due to M.
tuberculosis (Mtb), which kills millions of people each year. BCG variably protects children …

Mycobacterium tuberculosis PPE18 protein inhibits MHC class II antigen presentation and B cell response in mice

K Dolasia, F Nazar… - European Journal of …, 2021 - Wiley Online Library
PPE18 protein belongs to PE/PPE family of Mycobacterium tuberculosis. We reported earlier
that PPE18 protein provides survival advantage to M. tuberculosis during infection. In the …

An attenuated Mycobacterium tuberculosis clinical strain with a defect in ESX-1 secretion induces minimal host immune responses and pathology

HS Clemmensen, NPH Knudsen, EM Rasmussen… - Scientific Reports, 2017 - nature.com
Although Mycobacterium tuberculosis (M. tb) DK9897 is an attenuated strain, it was isolated
from a patient with extrapulmonary tuberculosis and vaccination with a subunit vaccine …

Immunological MHC supertypes and allelic expression: how low is the functional MHC diversity in free-ranging Namibian cheetahs?

N Schwensow, A Castro-Prieto, B Wachter… - Conservation …, 2019 - Springer
Cheetahs (Acinonyx jubatus) are a textbook example of how habitat loss, human-wildlife
conflicts and historic bottlenecks depleted genetic variability, both genome-wide and at the …

A temperature sensitive Mycobacterium paragordonae induces enhanced protective immune responses against mycobacterial infections in the mouse model

BJ Kim, BR Kim, YH Kook, BJ Kim - Scientific Reports, 2017 - nature.com
Recently, we introduced a temperature sensitive Mycobacterium spp., Mycobacterium
paragordonae (Mpg). Here, we checked its potential as a candidate for live vaccination …

A method permissive to fixation and permeabilization for the multiparametric analysis of apoptotic and necrotic cell phenotype by flow cytometry

S Mariotti, M Pardini, R Teloni, MC Gagliardi… - Cytometry Part …, 2017 - Wiley Online Library
Annexin‐V/propidium iodide method (A‐V/PI) is a common flow cytometric method for the
multiparametric analysis of cells in apoptosis. However, A‐V/PI does not permit fixation …