Novel In Silico mRNA vaccine design exploiting proteins of M. tuberculosis that modulates host immune responses by inducing epigenetic modifications
H Al Tbeishat - Scientific Reports, 2022 - nature.com
Tuberculosis is an airborne infectious disease caused by Mycobacterium tuberculosis. BCG
is the only approved vaccine. However, it has limited global efficacy. Pathogens could affect …
is the only approved vaccine. However, it has limited global efficacy. Pathogens could affect …
The inter-talk between Mycobacterium tuberculosis and the epigenetic mechanisms
Epigenetics regulate gene function without any alteration in the DNA sequence. The
epigenetics represent one of the most important regulators in different cellular processes …
epigenetics represent one of the most important regulators in different cellular processes …
Development of new preventive and therapeutic vaccines for tuberculosis
BE Kwon, JH Ahn, S Min, H Kim, J Seo… - Immune …, 2018 - synapse.koreamed.org
Tuberculosis (TB) is a contagious disease that has been responsible for the death of one
billion people in the last 200 years. Until now, the only vaccine approved for the prevention …
billion people in the last 200 years. Until now, the only vaccine approved for the prevention …
Mycobacterium tuberculosis Modulates miR-106b-5p to Control Cathepsin S Expression Resulting in Higher Pathogen Survival and Poor T-Cell Activation
D Pires, EM Bernard, JP Pombo, N Carmo… - Frontiers in …, 2017 - frontiersin.org
The success of tuberculosis (TB) bacillus, Mycobacterium tuberculosis (Mtb), relies on the
ability to survive in host cells and escape to immune surveillance and activation. We recently …
ability to survive in host cells and escape to immune surveillance and activation. We recently …
An autophagy-inducing and TLR-2 activating BCG vaccine induces a robust protection against tuberculosis in mice
Mycobacterium bovis BCG is widely used as a vaccine against tuberculosis due to M.
tuberculosis (Mtb), which kills millions of people each year. BCG variably protects children …
tuberculosis (Mtb), which kills millions of people each year. BCG variably protects children …
Mycobacterium tuberculosis PPE18 protein inhibits MHC class II antigen presentation and B cell response in mice
K Dolasia, F Nazar… - European Journal of …, 2021 - Wiley Online Library
PPE18 protein belongs to PE/PPE family of Mycobacterium tuberculosis. We reported earlier
that PPE18 protein provides survival advantage to M. tuberculosis during infection. In the …
that PPE18 protein provides survival advantage to M. tuberculosis during infection. In the …
An attenuated Mycobacterium tuberculosis clinical strain with a defect in ESX-1 secretion induces minimal host immune responses and pathology
HS Clemmensen, NPH Knudsen, EM Rasmussen… - Scientific Reports, 2017 - nature.com
Although Mycobacterium tuberculosis (M. tb) DK9897 is an attenuated strain, it was isolated
from a patient with extrapulmonary tuberculosis and vaccination with a subunit vaccine …
from a patient with extrapulmonary tuberculosis and vaccination with a subunit vaccine …
Immunological MHC supertypes and allelic expression: how low is the functional MHC diversity in free-ranging Namibian cheetahs?
N Schwensow, A Castro-Prieto, B Wachter… - Conservation …, 2019 - Springer
Cheetahs (Acinonyx jubatus) are a textbook example of how habitat loss, human-wildlife
conflicts and historic bottlenecks depleted genetic variability, both genome-wide and at the …
conflicts and historic bottlenecks depleted genetic variability, both genome-wide and at the …
A temperature sensitive Mycobacterium paragordonae induces enhanced protective immune responses against mycobacterial infections in the mouse model
Recently, we introduced a temperature sensitive Mycobacterium spp., Mycobacterium
paragordonae (Mpg). Here, we checked its potential as a candidate for live vaccination …
paragordonae (Mpg). Here, we checked its potential as a candidate for live vaccination …
A method permissive to fixation and permeabilization for the multiparametric analysis of apoptotic and necrotic cell phenotype by flow cytometry
S Mariotti, M Pardini, R Teloni, MC Gagliardi… - Cytometry Part …, 2017 - Wiley Online Library
Annexin‐V/propidium iodide method (A‐V/PI) is a common flow cytometric method for the
multiparametric analysis of cells in apoptosis. However, A‐V/PI does not permit fixation …
multiparametric analysis of cells in apoptosis. However, A‐V/PI does not permit fixation …