Toll‐Like Receptor 4: A Promising Therapeutic Target for Alzheimer's Disease

L Wu, X Xian, G Xu, Z Tan, F Dong… - Mediators of …, 2022 - Wiley Online Library
Alzheimer's disease (AD) is a progressive neurodegenerative disease that primarily
manifests as memory deficits and cognitive impairment and has created health challenges …

[HTML][HTML] Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia: review of clinical manifestations as foundations for therapeutic development

S Papapetropoulos, A Pontius, E Finger… - Frontiers in …, 2022 - frontiersin.org
A comprehensive review of published literature was conducted to elucidate the genetics,
neuropathology, imaging findings, prevalence, clinical course, diagnosis/clinical evaluation …

Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models

MC Silva, FM Ferguson, Q Cai, KA Donovan, G Nandi… - elife, 2019 - elifesciences.org
Tauopathies are neurodegenerative diseases characterized by aberrant forms of tau protein
accumulation leading to neuronal death in focal brain areas. Positron emission tomography …

Outdoor green space exposure and brain health measures related to Alzheimer's disease: A rapid review

L Besser - BMJ open, 2021 - bmjopen.bmj.com
Objectives Summarise studies of outdoor green space exposure and brain health measures
related to Alzheimer's disease and related disorders (ADRD), and determine scientific gaps …

[HTML][HTML] Dementia caregiving across Latin America and the Caribbean and brain health diplomacy

A Ibáñez, SD Pina-Escudero, KL Possin… - The Lancet Healthy …, 2021 - thelancet.com
The prevalence of dementia in Latin America and the Caribbean is growing rapidly,
increasing the burden placed on caregivers. Exacerbated by fragile health-care systems …

Advances in treatment of frontotemporal dementia

N Magrath Guimet… - The Journal of …, 2022 - Am Neuropsych Assoc
In this review, the authors explored the clinical features of frontotemporal dementia (FTD),
focusing on treatment. The clinical features of FTD are unique, with disinhibition, apathy …

New developments of biofluid‐based biomarkers for routine diagnosis and disease trajectories in frontotemporal dementia

M Del Campo, H Zetterberg, S Gandy… - Alzheimer's & …, 2022 - Wiley Online Library
Frontotemporal dementia (FTD) covers a spectrum of neurodegenerative disorders with
different phenotypes, genetic backgrounds, and pathological states. Its clinicopathological …

[HTML][HTML] Behavioral treatment for speech and language in primary progressive aphasia and primary progressive apraxia of speech: A systematic review

LD Wauters, K Croot, HR Dial, JR Duffy… - Neuropsychology …, 2023 - Springer
Primary progressive aphasia (PPA) and primary progressive apraxia of speech (PPAOS) are
neurodegenerative syndromes characterized by progressive decline in language or speech …

[HTML][HTML] Tail-vein injection of MSC-derived small extracellular vesicles facilitates the restoration of hippocampal neuronal morphology and function in APP/PS1 mice

H Wang, Y Liu, J Li, T Wang, Y Hei, H Li, X Wang… - Cell death …, 2021 - nature.com
Mesenchymal stem-cell-derived small extracellular vesicles (MSC-EVs), as a therapeutic
agent, have shown great promise in the treatment of neurological diseases. To date, the …

[HTML][HTML] Shared genetic links between frontotemporal dementia and psychiatric disorders

C Li, D Pang, J Lin, T Yang, H Shang - BMC medicine, 2022 - Springer
Background Epidemiological and clinical studies have suggested comorbidity between
frontotemporal dementia (FTD) and psychiatric disorders. FTD patients carrying specific …