Causes and consequences of snake venom variation
Snake venoms are mixtures of toxins that vary extensively between and within snake
species. This variability has serious consequences for the management of the world's 1.8 …
species. This variability has serious consequences for the management of the world's 1.8 …
The rise of genomics in snake venom research: recent advances and future perspectives
Snake venoms represent a danger to human health, but also a gold mine of bioactive
proteins that can be harnessed for drug discovery purposes. The evolution of snakes and …
proteins that can be harnessed for drug discovery purposes. The evolution of snakes and …
Phylogenetically diverse diets favor more complex venoms in North American pitvipers
ML Holding, JL Strickland… - Proceedings of the …, 2021 - National Acad Sciences
The role of natural selection in the evolution of trait complexity can be characterized by
testing hypothesized links between complex forms and their functions across species …
testing hypothesized links between complex forms and their functions across species …
Tracking the recruitment and evolution of snake toxins using the evolutionary context provided by the Bothrops jararaca genome
DD Almeida, VL Viala, PG Nachtigall… - Proceedings of the …, 2021 - National Acad Sciences
Venom is a key adaptive innovation in snakes, and how nonvenom genes were co-opted to
become part of the toxin arsenal is a significant evolutionary question. While this process …
become part of the toxin arsenal is a significant evolutionary question. While this process …
The roles of balancing selection and recombination in the evolution of rattlesnake venom
The origin of snake venom involved duplication and recruitment of non-venom genes into
venom systems. Several studies have predicted that directional positive selection has …
venom systems. Several studies have predicted that directional positive selection has …
Adaptive evolution of distinct prey-specific toxin genes in rear-fanged snake venom
Venom proteins evolve rapidly, and as a trophic adaptation are excellent models for
predator–prey evolutionary studies. The key to a deeper understanding of venom evolution …
predator–prey evolutionary studies. The key to a deeper understanding of venom evolution …
Large-scale snake genome analyses provide insights into vertebrate development
Snakes are a remarkable squamate lineage with unique morphological adaptations,
especially those related to the evolution of vertebrate skeletons, organs, and sensory …
especially those related to the evolution of vertebrate skeletons, organs, and sensory …
Molecular adaptations for sensing and securing prey and insight into amniote genome diversity from the garter snake genome
Colubridae represents the most phenotypically diverse and speciose family of snakes, yet
no well-assembled and annotated genome exists for this lineage. Here, we report and …
no well-assembled and annotated genome exists for this lineage. Here, we report and …
An ancient, conserved gene regulatory network led to the rise of oral venom systems
A Barua, AS Mikheyev - Proceedings of the National …, 2021 - National Acad Sciences
Oral venom systems evolved multiple times in numerous vertebrates, enabling the
exploitation of unique predatory niches. Yet how and when they evolved remains poorly …
exploitation of unique predatory niches. Yet how and when they evolved remains poorly …
[HTML][HTML] Mutual enlightenment: A toolbox of concepts and methods for integrating evolutionary and clinical toxinology via snake venomics and the contextual stance
Snakebite envenoming is a neglected tropical disease that may claim over 100,000 human
lives annually worldwide. Snakebite occurs as the result of an interaction between a human …
lives annually worldwide. Snakebite occurs as the result of an interaction between a human …