Diffuse large B-cell lymphoma
S Li, KH Young, LJ Medeiros - Pathology, 2018 - Elsevier
Diffuse large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma
worldwide, representing approximately 30–40% of all cases in different geographic regions …
worldwide, representing approximately 30–40% of all cases in different geographic regions …
[HTML][HTML] Genetic alterations and their clinical implications in DLBCL
Y Miao, LJ Medeiros, Y Li, J Li, KH Young - Nature reviews Clinical …, 2019 - nature.com
Diffuse large B cell lymphoma (DLBCL) is a highly heterogeneous lymphoid neoplasm with
variations in gene expression profiles and genetic alterations, which lead to substantial …
variations in gene expression profiles and genetic alterations, which lead to substantial …
[HTML][HTML] When mutants gain new powers: news from the mutant p53 field
R Brosh, V Rotter - Nature reviews cancer, 2009 - nature.com
Ample data indicate that mutant p53 proteins not only lose their tumour suppressive
functions, but also gain new abilities that promote tumorigenesis. Moreover, recent studies …
functions, but also gain new abilities that promote tumorigenesis. Moreover, recent studies …
Mutational profile and prognostic significance of TP53 in diffuse large B-cell lymphoma patients treated with R-CHOP: report from an International DLBCL Rituximab …
ZY Xu-Monette, L Wu, C Visco, YC Tai… - Blood, The Journal …, 2012 - ashpublications.org
TP53 mutation is an independent marker of poor prognosis in patients with diffuse large B-
cell lymphoma (DLBCL) treated with cyclophosphamide, hydroxydaunorubicin, vincristine …
cell lymphoma (DLBCL) treated with cyclophosphamide, hydroxydaunorubicin, vincristine …
The p53/p21 complex regulates cancer cell invasion and apoptosis by targeting Bcl-2 family proteins
EM Kim, CH Jung, J Kim, SG Hwang, JK Park, HD Um - Cancer research, 2017 - AACR
The tumor suppressor p53 binds prosurvival Bcl-2 family proteins such as Bcl-w and Bcl-XL
to liberate Bax, which in turn exerts proapoptotic or anti-invasive functions depending on …
to liberate Bax, which in turn exerts proapoptotic or anti-invasive functions depending on …
Monomorphic epitheliotropic intestinal T-cell lymphoma comprises morphologic and genomic heterogeneity impacting outcome
L Veloza, D Cavalieri, E Missiaglia… - …, 2022 - pmc.ncbi.nlm.nih.gov
Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare aggressive T-cell
lymphoma most reported in Asia. We performed a comprehensive clinical, pathological and …
lymphoma most reported in Asia. We performed a comprehensive clinical, pathological and …
APR-246 triggers ferritinophagy and ferroptosis of diffuse large B-cell lymphoma cells with distinct TP53 mutations
Y Hong, T Ren, X Wang, X Liu, Y Fei, S Meng, X Han… - Leukemia, 2022 - nature.com
TP53 mutations correlate with inferior survival in many cancers. APR-246 is a compound to
shift mutant p53 and exhibits anti-cancer effects. Among its effects, APR-246 facilitates the …
shift mutant p53 and exhibits anti-cancer effects. Among its effects, APR-246 facilitates the …
Therapeutic potential of an anti-CD79b antibody–drug conjugate, anti–CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma
D Dornan, F Bennett, Y Chen, M Dennis… - Blood, The Journal …, 2009 - ashpublications.org
Here we describe the generation of an antibody–drug conjugate (ADC) consisting of a
humanized anti-CD79b antibody that is conjugated to monomethylauristatin E (MMAE) …
humanized anti-CD79b antibody that is conjugated to monomethylauristatin E (MMAE) …
Structural profiles of TP53 gene mutations predict clinical outcome in diffuse large B-cell lymphoma: an international collaborative study
KH Young, K Leroy, MB Møller… - Blood, The Journal …, 2008 - ashpublications.org
The purpose of this study is to correlate the presence of TP53 gene mutations with the
clinical outcome of a cohort of patients with diffuse large B-cell lymphoma (DLBCL) …
clinical outcome of a cohort of patients with diffuse large B-cell lymphoma (DLBCL) …
Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome
A Rinaldi, M Mian, E Chigrinova… - Blood, The Journal …, 2011 - ashpublications.org
Marginal zone B-cell lymphomas (MZLs) have been divided into 3 distinct subtypes
(extranodal MZLs of mucosa-associated lymphoid tissue [MALT] type, nodal MZLs, and …
(extranodal MZLs of mucosa-associated lymphoid tissue [MALT] type, nodal MZLs, and …