With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …

This review aims at juxtaposing common versus distinct structural and functional strategies
that are applied by aptamers, riboswitches, and ribozymes/DNAzymes. Focusing on recently …

Insight into the three-dimensional architecture of RNA is essential for understanding its
cellular functions. However, even the classic transfer RNA structure contains features that …

We describe an experimental method of three-dimensional (3D) structure determination that
exploits the increasing ease of high-throughput mutational scans. Inspired by the success of …

Ribozymes are catalytic RNAs with diverse functions including self-splicing and
polymerization. This work aims to discover natural ribozymes that behave as hydrolytic and …

Enzymes made of RNA catalyze reactions that are essential for protein synthesis and RNA
processing. However, such natural ribozymes are exceedingly rare, as evidenced by the fact …

Self-cleaving ribozymes were discovered 30 years ago, but their biological distribution and
catalytic mechanisms are only beginning to be defined. Each ribozyme family is defined by a …

Catalysis in biology is restricted to RNA (ribozymes) and protein enzymes, but synthetic
biomolecular catalysts can also be made of DNA (deoxyribozymes) or synthetic genetic …

The Varkud satellite (VS) ribozyme mediates rolling-circle replication of a plasmid found in
the Neurospora mitochondrion. We report crystal structures of this ribozyme from …

Nucleolytic ribozymes utilize general acid‐base catalysis to perform phosphodiester
cleavage. In most ribozyme classes, a conserved active site guanosine is positioned to act …