Inflammation, not cholesterol, is a cause of chronic disease

A Tsoupras, R Lordan, I Zabetakis - Nutrients, 2018 - mdpi.com
Since the Seven Countries Study, dietary cholesterol and the levels of serum cholesterol in
relation to the development of chronic diseases have been somewhat demonised. However …

[HTML][HTML] Dairy fats and cardiovascular disease: do we really need to be concerned?

R Lordan, A Tsoupras, B Mitra, I Zabetakis - Foods, 2018 - mdpi.com
Cardiovascular diseases (CVD) remain a major cause of death and morbidity globally and
diet plays a crucial role in the disease prevention and pathology. The negative perception of …

Chlorogenic acid attenuates dextran sodium sulfate‐induced ulcerative colitis in mice through MAPK/ERK/JNK pathway

W Gao, C Wang, L Yu, T Sheng, Z Wu… - BioMed Research …, 2019 - Wiley Online Library
Objective. Observe the protective effect of chlorogenic acid on dextran sulfate‐induced
ulcerative colitis in mice and explore the regulation of MAPK/ERK/JNK signaling pathway …

Platelet activation and prothrombotic mediators at the nexus of inflammation and atherosclerosis: Potential role of antiplatelet agents

R Lordan, A Tsoupras, I Zabetakis - Blood reviews, 2021 - Elsevier
Platelets are central to inflammation-related manifestations of cardiovascular diseases
(CVD) such as atherosclerosis. Platelet-activating factor (PAF), thrombin, thromboxane A 2 …

Phospholipids of animal and marine origin: Structure, function, and anti-inflammatory properties

R Lordan, A Tsoupras, I Zabetakis - Molecules, 2017 - mdpi.com
In this review paper, the latest literature on the functional properties of phospholipids in
relation to inflammation and inflammation-related disorders has been critically appraised …

Forty years since the structural elucidation of platelet-activating factor (PAF): historical, current, and future research perspectives

R Lordan, A Tsoupras, I Zabetakis, CA Demopoulos - Molecules, 2019 - mdpi.com
In the late 1960s, Barbaro and Zvaifler described a substance that caused antigen induced
histamine release from rabbit platelets producing antibodies in passive cutaneous …

Platelet inflammatory response to stress

F Cognasse, S Laradi, P Berthelot, T Bourlet… - Frontiers in …, 2019 - frontiersin.org
Blood platelets play a central hemostatic role,(i) as they repair vascular epithelial damage,
and (ii) they play immune defense roles, as they have the capacity to produce and secrete …

Inflammation and cardiovascular disease: are marine phospholipids the answer?

R Lordan, S Redfern, A Tsoupras, I Zabetakis - Food & function, 2020 - pubs.rsc.org
Since the discovery that Greenlandic Innuits had a lower risk of developing cardiovascular
diseases (CVD) due to their diet of fish and as a consequence high polyunsaturated fatty …

Phospholipid signaling in innate immune cells

VB O'Donnell, J Rossjohn… - The Journal of clinical …, 2019 - Am Soc Clin Investig
Phospholipids comprise a large body of lipids that define cells and organelles by forming
membrane structures. Importantly, their complex metabolism represents a highly controlled …

Cardiovascular risk and testosterone–from subclinical atherosclerosis to lipoprotein function to heart failure

B Gencer, M Bonomi, MP Adorni, CR Sirtori… - Reviews in Endocrine …, 2021 - Springer
The cardiovascular (CV) benefit and safety of treating low testosterone conditions is a matter
of debate. Although testosterone deficiency has been linked to a rise in major adverse CV …