The liver is often thought of as a single functional unit, but both its structural and functional
architecture make it highly multivalent and adaptable. In any given physiological situation …

Sexually dimorphic traits are common among mammals and are specified during
development through the deployment of sex-specific genetic programs. Because little is …

The circadian clock and associated feeding rhythms have a profound impact on metabolism
and the gut microbiome. To what extent microbiota reciprocally affect daily rhythms of …

Plasticity in developmental programming has evolved in order to provide the best chances of
survival and reproductive success to the organism under changing environments …

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths
worldwide. Only 30%-40% of the patients with HCC are eligible for curative treatments …

A. Genetic, molecular, and transgenic models B. Human GH rhythms III. Neuropeptide
Regulation of the GH Axis: Somatostatin and GHRH

Mammals undergo regular cycles of fasting and feeding that engage dynamic transcriptional
responses in metabolic tissues. Here we review advances in our understanding of the gene …

The body growth of animals is regulated by growth hormone and IGF-I. The classical theory
of this regulation is that most IGF-I in the blood originates in the liver and that body growth is …

Loss of estrogens or androgens increases the rate of bone remodeling by removing
restraining effects on osteoblastogenesis and osteoclastogenesis, and also causes a focal …