Alzheimer's disease (AD) starts from pure cognitive impairments and gradually progresses
into degeneration of specific brain circuits. Although numerous factors initiating AD have …

Identifying the interactions established by a protein of interest can be a critical step in
understanding its function. This is especially true when an unknown protein of interest is …

Protein aggregation and dysfunction of the ubiquitin-proteasome system are hallmarks of
many neurodegenerative diseases. Here, we address the elusive link between these …

Sample purity is central to in vitro studies of protein function and regulation, and to the
efficiency and success of structural studies using techniques such as x-ray crystallography …

The ubiquitin-proteasome system and autophagy are the two main proteolytic systems
involved in, among other functions, the maintenance of cell integrity by eliminating misfolded …

Interactomes are often measured using affinity purification–mass spectrometry (AP-MS) or
yeast two-hybrid approaches, but these methods do not provide stoichiometric or temporal …

Oxidative stress has been implicated in aging and many human diseases, notably
neurodegenerative disorders and various cancers. The reactive oxygen species that are …

Proteostasis is maintained by multiple cellular pathways, including protein synthesis, quality
control, and degradation. An imbalance of neuronal proteostasis, associated with protein …

The 26 S proteasome is a key player in eukaryotic protein quality control and in the
regulation of numerous cellular processes. Here, we describe quantitative in situ structural …

Ubiquitylation (also known as ubiquitination) regulates essentially all of the intracellular
processes in eukaryotes through highly specific modification of numerous cellular proteins …