Fluorine-containing pharmaceuticals approved by the FDA in 2020: Synthesis and biological activity
Thirteen new fluorine-containing drugs, which have been granted approval by the US Food
and Drug Administration (FDA) in 2020, are profiled in this review. Therapeutic areas of …
and Drug Administration (FDA) in 2020, are profiled in this review. Therapeutic areas of …
[HTML][HTML] Contact pathway of coagulation and inflammation
Y Wu - Thrombosis journal, 2015 - Springer
The contact system, also named as plasma kallikrein-kinin system, consists of three serine
proteinases: coagulation factors XII (FXII) and XI (FXI), and plasma prekallikrein (PK), and …
proteinases: coagulation factors XII (FXII) and XI (FXI), and plasma prekallikrein (PK), and …
[HTML][HTML] Proteomics and machine learning approaches reveal a set of prognostic markers for COVID-19 severity with drug repurposing potential
The pestilential pathogen SARS-CoV-2 has led to a seemingly ceaseless pandemic of
COVID-19. The healthcare sector is under a tremendous burden, thus necessitating the …
COVID-19. The healthcare sector is under a tremendous burden, thus necessitating the …
Electrochemical synthesis of hindered primary and secondary amines via proton-coupled electron transfer
Accessing hindered amines, particularly primary amines α to a fully substituted carbon
center, is synthetically challenging. We report an electrochemical method to access such …
center, is synthetically challenging. We report an electrochemical method to access such …
[HTML][HTML] Vanadium as potential therapeutic agent for COVID-19: A focus on its antiviral, antiinflamatory, and antihyperglycemic effects
S Semiz - Journal of Trace Elements in Medicine and Biology, 2022 - Elsevier
An increasing evidence suggests that vanadium compounds are novel potential drugs in the
treatment of diabetes, atherosclerosis, and cancer. Vanadium has also demonstrated …
treatment of diabetes, atherosclerosis, and cancer. Vanadium has also demonstrated …
Redoxisome and diabetic retinopathy: Pathophysiology and therapeutic interventions
I Sharma, KS Yadav, MN Mugale - Pharmacological Research, 2022 - Elsevier
Diabetic retinopathy (DR) is a chronic microvascular complication of diabetes mellitus (DM).
It is a worldwide growing epidemic disease considered to be the leading cause of vision …
It is a worldwide growing epidemic disease considered to be the leading cause of vision …
[HTML][HTML] Parkinson's disease: a systemic inflammatory disease accompanied by bacterial inflammagens
Parkinson's disease (PD) is a well-known neurodegenerative disease with a strong
association established with systemic inflammation. Recently, the role of the gingipain …
association established with systemic inflammation. Recently, the role of the gingipain …
[HTML][HTML] Inhibition of metalloproteinases in therapy for severe lung injury due to COVID-19
B Solun, Y Shoenfeld - Medicine in drug discovery, 2020 - Elsevier
Since its first appearance in December 2019 in the Chinese province of Wuhan, COVID-19
has spread rapidly throughout the world and poses a serious threat to public health. Acute …
has spread rapidly throughout the world and poses a serious threat to public health. Acute …
[HTML][HTML] A comprehensive review on current understanding of bradykinin in COVID-19 and inflammatory diseases
DAB Rex, N Vaid, K Deepak, S Dagamajalu… - Molecular Biology …, 2022 - Springer
Bradykinin, a member of the kallikrein–kinin system (KKS), is a potent, short-lived vasoactive
peptide that acts as a vasodilator and an inflammatory mediator in a number of signaling …
peptide that acts as a vasodilator and an inflammatory mediator in a number of signaling …
Implication of the Kallikrein-Kinin system in neurological disorders: Quest for potential biomarkers and mechanisms
A Nokkari, H Abou-El-Hassan, Y Mechref… - Progress in …, 2018 - Elsevier
Neurological disorders represent major health concerns in terms of comorbidity and
mortality worldwide. Despite a tremendous increase in our understanding of the …
mortality worldwide. Despite a tremendous increase in our understanding of the …