Thirteen new fluorine-containing drugs, which have been granted approval by the US Food
and Drug Administration (FDA) in 2020, are profiled in this review. Therapeutic areas of …

The contact system, also named as plasma kallikrein-kinin system, consists of three serine
proteinases: coagulation factors XII (FXII) and XI (FXI), and plasma prekallikrein (PK), and …

The pestilential pathogen SARS-CoV-2 has led to a seemingly ceaseless pandemic of
COVID-19. The healthcare sector is under a tremendous burden, thus necessitating the …

Accessing hindered amines, particularly primary amines α to a fully substituted carbon
center, is synthetically challenging. We report an electrochemical method to access such …

An increasing evidence suggests that vanadium compounds are novel potential drugs in the
treatment of diabetes, atherosclerosis, and cancer. Vanadium has also demonstrated …

Diabetic retinopathy (DR) is a chronic microvascular complication of diabetes mellitus (DM).
It is a worldwide growing epidemic disease considered to be the leading cause of vision …

Parkinson's disease (PD) is a well-known neurodegenerative disease with a strong
association established with systemic inflammation. Recently, the role of the gingipain …

Since its first appearance in December 2019 in the Chinese province of Wuhan, COVID-19
has spread rapidly throughout the world and poses a serious threat to public health. Acute …

Bradykinin, a member of the kallikrein–kinin system (KKS), is a potent, short-lived vasoactive
peptide that acts as a vasodilator and an inflammatory mediator in a number of signaling …

Neurological disorders represent major health concerns in terms of comorbidity and
mortality worldwide. Despite a tremendous increase in our understanding of the …