Since diabetic cardiomyopathy was first reported four decades ago, substantial information
on its pathogenesis and clinical features has accumulated. In the heart, diabetes enhances …

Obesity is a growing epidemiological problem, as two-thirds of the adult population are
carrying excess weight. It is a risk factor for the development of cardiovascular diseases …

Adipocytes undergo intense energetic stress in obesity resulting in loss of mitochondrial
mass and function. We have found that adipocytes respond to mitochondrial stress by …

Background—Rheb is a GTP-binding protein that promotes cell survival and mediates the
cellular response to energy deprivation (ED). The role of Rheb in the regulation of cell …

Pro‐inflammatory and stress‐activated signalling pathways are important role players in the
pathogenesis of obesity and insulin resistance. Obesity and type II diabetes are associated …

Obesity, a major risk factor for ischemic heart disease, is associated with increased oxidative
stress and reduced antioxidant status. Melatonin, a potent free radical scavenger and …

The morbidity and mortality from cardiovascular diseases (CVD) remain high. Metabolic
diseases such as obesity, hyperlipidemia, diabetes mellitus (DM), non-alcoholic fatty liver …

Although incidence and prevalence of prediabetes are increasing, little is known about its
cardiac effects. Therefore, our aim was to investigate the effect of prediabetes on cardiac …

Background Obese-insulin resistance caused by long-term high-fat diet (HFD) consumption
is associated with left ventricular (LV) dysfunction and increased risk of myocardial …

Ischemic postconditioning (IPCD) significantly reduces infarct size in healthy animals and
protects the human heart. Because obesity is a major risk factor of cardiovascular diseases …