Complex interactions between the immune system and the brain might have important
aetiological and therapeutic implications for neuropsychiatric brain disorders. A possible …

Epidemiologic studies, including prospective birth cohort investigations, have implicated
maternal immune activation in the etiology of neuropsychiatric disorders. Maternal infectious …

Importance Previous in vitro and postmortem research suggests that inflammation may lead
to structural brain changes via activation of microglia and/or astrocytic dysfunction in a range …

It is increasingly appreciated that altered neuroimmune mechanisms might play a role in the
development of schizophrenia and related psychotic illnesses. On the basis of human …

Developing reliable, predictive animal models for complex psychiatric disorders, such as
schizophrenia, is essential to increase our understanding of the neurobiological basis of the …

The core symptoms of autism are deficits in social interaction and language, and the
presence of repetitive/stereotyped behaviors. We demonstrate that behaviors related to …

Schizophrenia is a complex and multifactorial disorder generally diagnosed in young adults
at the time of the first psychotic episode of delusions and hallucinations. These positive …

In the present article the putative role of environmental factors in schizophrenia is reviewed
and synthesized. Accumulating evidence from recent studies suggests that environmental …

BackgroundDisruption of foetal development by prenatal maternal infection is consistent
with a neurodevelopmental model of schizophrenia. Whether specific prenatal infections are …

Recent studies have highlighted a connection between infection during pregnancy and the
increased risk of autism in the offspring. Parallel studies of cerebral spinal fluid, blood and …