Population stratification in genetic association studies
Population stratification (PS) is a primary consideration in studies of genetic determinants of
human traits. Failure to control for PS may lead to confounding, causing a study to fail for …
human traits. Failure to control for PS may lead to confounding, causing a study to fail for …
A systematic literature review on the European, African and Amerindian genetic ancestry components on Brazilian health outcomes
FSCF Pereira, RM Guimarães, AR Lucidi, DG Brum… - Scientific Reports, 2019 - nature.com
The variables such as race, skin colour and ethnicity have become intensely discussed in
medicine research, as a response to the rising debate over the importance of the ethnic …
medicine research, as a response to the rising debate over the importance of the ethnic …
Prevalence of inflammatory pathways over immuno-tolerance in peripheral blood mononuclear cells of recent-onset type 1 diabetes
AS Santos, E Cunha-Neto, NV Gonfinetti… - Frontiers in …, 2022 - frontiersin.org
Background Changes in innate and adaptive immunity occurring in/around pancreatic islets
had been observed in peripheral blood mononuclear cells (PBMC) of Caucasian T1D …
had been observed in peripheral blood mononuclear cells (PBMC) of Caucasian T1D …
Self-reported color-race and genomic ancestry in an admixed population: A contribution of a nationwide survey in patients with type 1 diabetes in Brazil
MB Gomes, AB Gabrielli, DC Santos, MH Pizarro… - Diabetes research and …, 2018 - Elsevier
Aims The development of type 1 diabetes (T1D) and its chronic complications may have a
genetic background. The primary objective of our study was to characterize the relationship …
genetic background. The primary objective of our study was to characterize the relationship …
Cannabinoid receptor gene polymorphisms and cognitive performance in patients with schizophrenia and controls
R Ferretjans, RP de Souza, B Panizzutti… - Brazilian Journal of …, 2021 - SciELO Brasil
Objective: To test the hypothesis that genetic variations of cannabinoid receptors contribute
to the pathophysiology of cognitive deficits in schizophrenia. Methods: In this genetic …
to the pathophysiology of cognitive deficits in schizophrenia. Methods: In this genetic …
HLA class II genotyping of admixed Brazilian patients with type 1 diabetes according to self-reported color/race in a nationwide study
DC Santos, LC Porto, RV Oliveira, D Secco… - Scientific Reports, 2020 - nature.com
The HLA region is responsible for almost 50% of the genetic risk of type 1 diabetes (T1D).
However, haplotypes and their effects on risk or protection vary among different ethnic …
However, haplotypes and their effects on risk or protection vary among different ethnic …
Shared and distinct genetics of pure type 1 diabetes and type 1 diabetes with celiac disease, homology in their auto-antigens and immune dysregulation states: a …
Aim This study was undertaken to explicate the shared and distinctive genetic susceptibility
and immune dysfunction in patients with T1D alone and T1D with CD (T1D+ CD). Methods A …
and immune dysfunction in patients with T1D alone and T1D with CD (T1D+ CD). Methods A …
Association and interaction of genetic variants with occurrence of ischemic stroke among Brazilian patients
LE Ferreira, R Secolin, I Lopes-Cendes, NL Cabral… - Gene, 2019 - Elsevier
Ischemic Stroke (IS) is a severe and complex disorder of high morbidity and mortality rates
associated with clinical, environmental, and genetic predisposing factors. Despite previous …
associated with clinical, environmental, and genetic predisposing factors. Despite previous …
Association between HLA Class II alleles/haplotypes and genomic ancestry in Brazilian patients with type 1 diabetes: a nationwide exploratory study
MB Gomes, V Rodrigues, DC Santos, PRV Bôas… - Genes, 2023 - mdpi.com
We aimed to identify HLA-DRB1,-DQA1, and-DQB1 alleles/haplotypes associated with
European, African, or Native American genomic ancestry (GA) in admixed Brazilian patients …
European, African, or Native American genomic ancestry (GA) in admixed Brazilian patients …
Unraveling the Immune Signature of Herpes Zoster: Insights Into the Pathophysiology and Human Leukocyte Antigen Risk Profile
R Vandoren, M Boeren, J Schippers… - The Journal of …, 2024 - academic.oup.com
The varicella-zoster virus (VZV) infects> 95% of the population. VZV reactivation causes
herpes zoster (HZ), known as shingles, primarily affecting the elderly and individuals who …
herpes zoster (HZ), known as shingles, primarily affecting the elderly and individuals who …