Introduction Curcuma longa, popularly known as Turmeric, is a rhizomatous herbaceous
perennial plant used in folk medicine for the treatment, prevention, and management of …

Reactive oxygen species (ROS) are noxious to cells because their increased level interacts
with the body's defense mechanism. These species also cause mutations and uncontrolled …

Parkinson's disease is a common progressive neurodegenerative disease, and presently
has no curative agent. Curcumin, as one of the natural polyphenols, has great potential in …

Cadmium (Cd) is an environmental heavy metal toxicant with central nervous system toxicity
and has a greater negative impact on fetal neurodevelopment. However, the causative …

Cadmium (Cd) is a potent neurotoxic metal present in the environment and food. In this
study, CdCl2 (2 or 4 μM) induced cytotoxicity and neurotoxicity in PC12 cells, causing …

Adequate food intake and relative abundance of dietary nutrients have undisputed effects on
the brain function. There is now substantial evidence that dietary nutrition aids in the …

Arsenic (As) is known for its carcinogenic and hepatorenal toxic effects causing serious
health problems in human beings. Turmeric (Curcuma longa L.) extracted curcumin (Cur) is …

Cyclic-AMP-response element-binding protein (CREB) is a leucine zipper class transcription
factor that is activated through phosphorylation. Ample CREB phosphorylation is required for …

Alzheimer's disease (AD) is a major form of dementia. Abnormal amyloidogenic event-
mediated degeneration of cholinergic neurons in the cognitive centers of the brain has been …

Neurodegeneration is a condition of the central nervous system (CNS) characterized by loss
of neural structures and function. The most common neurodegenerative disorders (NDDs) …