Objective The COVID-19 pandemic increased the demand for rapid evaluation of innovation
in health and social care. Assessment of rapid methodologies is lacking although …

Introduction: Anorexia and cachexia syndrome represents a complex clinical picture that
occurs in the late stage of several chronic inflammatory diseases, including cancer. Unless …

Background: Paracentesis is commonly undertaken in patients with cancer-related ascites.
Aim: To systematically investigate the symptomatic benefits and harms experienced by …

Introduction: Prescribing practice in hospice/palliative care is largely extrapolated from other
areas of clinical practice, with few studies of net medication effects (benefits and harms) in …

Background Pharmacotherapy is generally recommended to treat patients with delirium. We
sought to describe the current practice, effectiveness, and adverse effects of …

Context Malignant bowel obstruction impairs the quality of life in patients with advanced
cancer. Octreotide, acid-suppressing medications such as H 2-receptor antagonists (H 2 …

Background: Haloperidol is widely prescribed as an antiemetic in patients receiving
palliative care, but there is limited evidence to support and refine its use. Objective: To …

Objective Hospice/palliative care patients may differ from better studied populations, and
data from other populations cannot necessarily be extrapolated into hospice/palliative care …

Objectives Loss of appetite is prevalent in palliative care and distressing for patients and
families. Therapies include corticosteroids or progestogens. This study explores the net …

Background: Real-world effectiveness of interventions in palliative care need to be
systematically quantified to inform patient/clinical decisions. Neuropathic pain is prevalent …