Candida albicans and Candida glabrata: global priority pathogens
M Katsipoulaki, MHT Stappers… - Microbiology and …, 2024 - Am Soc Microbiol
SUMMARY A significant increase in the incidence of Candida-mediated infections has been
observed in the last decade, mainly due to rising numbers of susceptible individuals …
observed in the last decade, mainly due to rising numbers of susceptible individuals …
Candida albicans Enhances the Progression of Oral Squamous Cell Carcinoma In Vitro and In Vivo
M Vadovics, J Ho, N Igaz, R Alföldi, D Rakk, É Veres… - MBio, 2022 - Am Soc Microbiol
Oral squamous cell carcinoma (OSCC) is associated with oral Candida albicans infection,
although it is unclear whether the fungus promotes the genesis and progression of OSCC or …
although it is unclear whether the fungus promotes the genesis and progression of OSCC or …
Nanobody-mediated neutralization of candidalysin prevents epithelial damage and inflammatory responses that drive vulvovaginal candidiasis pathogenesis
M Valentine, P Rudolph, A Dietschmann, A Tsavou… - MBio, 2024 - Am Soc Microbiol
Candida albicans can cause mucosal infections in humans. This includes oropharyngeal
candidiasis, which is commonly observed in human immunodeficiency virus infected …
candidiasis, which is commonly observed in human immunodeficiency virus infected …
Candidalysins are a new family of cytolytic fungal peptide toxins
Candidalysin is the first cytolytic peptide toxin identified in any human fungal pathogen.
Candidalysin is secreted by Candida albicans and is critical for driving infection and host …
Candidalysin is secreted by Candida albicans and is critical for driving infection and host …
Nature of β-1, 3-glucan-exposing features on Candida albicans cell wall and their modulation
Candida albicans exists as a commensal of mucosal surfaces and the gastrointestinal tract
without causing pathology. However, this fungus is also a common cause of mucosal and …
without causing pathology. However, this fungus is also a common cause of mucosal and …
Toll-like receptor 4 and CD11b expressed on microglia coordinate eradication of Candida albicans cerebral mycosis
The fungal pathogen Candida albicans is linked to chronic brain diseases such as
Alzheimer's disease (AD), but the molecular basis of brain anti-Candida immunity remains …
Alzheimer's disease (AD), but the molecular basis of brain anti-Candida immunity remains …
Functional analysis of the Candida albicans ECE1 Promoter
E Garbe, N Thielemann, S Hohner, A Kumar… - Microbiology …, 2023 - Am Soc Microbiol
The formation of hyphae is a key virulence attribute of Candida albicans as they are required
for adhesion to and invasion of host cells, and ultimately deep-tissue dissemination. Hyphae …
for adhesion to and invasion of host cells, and ultimately deep-tissue dissemination. Hyphae …
Second-generation antidiabetic sulfonylureas inhibit Candida albicans and Candidalysin-mediated activation of the NLRP3 inflammasome
DJ Lowes, KE Hevener, BM Peters - Antimicrobial Agents and …, 2020 - Am Soc Microbiol
Repurposing of currently approved medications is an attractive option for the development of
novel treatment strategies against physiological and infectious diseases. The antidiabetic …
novel treatment strategies against physiological and infectious diseases. The antidiabetic …
The globular C1q receptor is required for epidermal growth factor receptor signaling during Candida albicans infection
During oropharyngeal candidiasis, Candida albicans activates the epidermal growth factor
receptor (EGFR), which induces oral epithelial cells to endocytose the fungus and …
receptor (EGFR), which induces oral epithelial cells to endocytose the fungus and …
Epidermal growth factor receptor signaling governs the host inflammatory response to invasive aspergillosis
The epidermal growth factor receptor (EGFR) has been identified as an epithelial cell
receptor for Mucorales fungi and Candida albicans. Blocking EGFR with small molecule …
receptor for Mucorales fungi and Candida albicans. Blocking EGFR with small molecule …