Candida albicans and Candida glabrata: global priority pathogens

M Katsipoulaki, MHT Stappers… - Microbiology and …, 2024 - Am Soc Microbiol
SUMMARY A significant increase in the incidence of Candida-mediated infections has been
observed in the last decade, mainly due to rising numbers of susceptible individuals …

Candida albicans Enhances the Progression of Oral Squamous Cell Carcinoma In Vitro and In Vivo

M Vadovics, J Ho, N Igaz, R Alföldi, D Rakk, É Veres… - MBio, 2022 - Am Soc Microbiol
Oral squamous cell carcinoma (OSCC) is associated with oral Candida albicans infection,
although it is unclear whether the fungus promotes the genesis and progression of OSCC or …

Nanobody-mediated neutralization of candidalysin prevents epithelial damage and inflammatory responses that drive vulvovaginal candidiasis pathogenesis

M Valentine, P Rudolph, A Dietschmann, A Tsavou… - MBio, 2024 - Am Soc Microbiol
Candida albicans can cause mucosal infections in humans. This includes oropharyngeal
candidiasis, which is commonly observed in human immunodeficiency virus infected …

Candidalysins are a new family of cytolytic fungal peptide toxins

JP Richardson, R Brown, N Kichik, S Lee, E Priest… - MBio, 2022 - Am Soc Microbiol
Candidalysin is the first cytolytic peptide toxin identified in any human fungal pathogen.
Candidalysin is secreted by Candida albicans and is critical for driving infection and host …

Nature of β-1, 3-glucan-exposing features on Candida albicans cell wall and their modulation

LJ de Assis, JM Bain, C Liddle, I Leaves, C Hacker… - MBio, 2022 - Am Soc Microbiol
Candida albicans exists as a commensal of mucosal surfaces and the gastrointestinal tract
without causing pathology. However, this fungus is also a common cause of mucosal and …

Toll-like receptor 4 and CD11b expressed on microglia coordinate eradication of Candida albicans cerebral mycosis

Y Wu, S Du, LH Bimler, KE Mauk, L Lortal, N Kichik… - Cell reports, 2023 - cell.com
The fungal pathogen Candida albicans is linked to chronic brain diseases such as
Alzheimer's disease (AD), but the molecular basis of brain anti-Candida immunity remains …

Functional analysis of the Candida albicans ECE1 Promoter

E Garbe, N Thielemann, S Hohner, A Kumar… - Microbiology …, 2023 - Am Soc Microbiol
The formation of hyphae is a key virulence attribute of Candida albicans as they are required
for adhesion to and invasion of host cells, and ultimately deep-tissue dissemination. Hyphae …

Second-generation antidiabetic sulfonylureas inhibit Candida albicans and Candidalysin-mediated activation of the NLRP3 inflammasome

DJ Lowes, KE Hevener, BM Peters - Antimicrobial Agents and …, 2020 - Am Soc Microbiol
Repurposing of currently approved medications is an attractive option for the development of
novel treatment strategies against physiological and infectious diseases. The antidiabetic …

The globular C1q receptor is required for epidermal growth factor receptor signaling during Candida albicans infection

QT Phan, J Lin, NV Solis, M Eng, M Swidergall, F Wang… - MBio, 2021 - Am Soc Microbiol
During oropharyngeal candidiasis, Candida albicans activates the epidermal growth factor
receptor (EGFR), which induces oral epithelial cells to endocytose the fungus and …

Epidermal growth factor receptor signaling governs the host inflammatory response to invasive aspergillosis

H Liu, J Lin, QT Phan, VM Bruno, SG Filler - mBio, 2024 - journals.asm.org
The epidermal growth factor receptor (EGFR) has been identified as an epithelial cell
receptor for Mucorales fungi and Candida albicans. Blocking EGFR with small molecule …