Degeneration of central cholinergic neurons impairs memory, and enhancement of
cholinergic synapses improves cognitive processes. Cholinergic signaling is also anti …

As indicated by the profound cognitive impairments caused by cholinergic receptor
antagonists, cholinergic neurotransmission has a vital role in cognitive function, specifically …

The Morris water maze (MWM) was described 20 years ago as a device to investigate
spatial learning and memory in laboratory rats. In the meanwhile, it has become one of the …

▪ Abstract The organization and possible functions of basal forebrain and pontine cholinergic
systems are reviewed. Whereas the basal forebrain cholinergic neuronal projections likely …

Aging is a complex biological process that increases the risk of age-related cognitive
degenerative diseases such as dementia, including Alzheimer's disease (AD), Lewy Body …

Alzheimer's disease (AD) is the most common form of degenerative dementia and is
characterized by progressive impairment in cognitive function during mid-to late-adult life …

Neurophysiological studies demonstrated that increases in cholinergic transmission in
sensory areas enhance the cortical processing of thalamic inputs. Cholinergic activity also …

Previous efforts aimed at attributing discrete behavioral functions to cortical cholinergic
afferents have not resulted in a generally accepted hypothesis about the behavioral …

From previous literature, it appears that most classical neurotransmitter systems can in some
way influence learning and memory in the rat. A matter of crucial interest is, however …

Saito et al developed a novel amyloid precursor protein (APP) knock-in mouse model (APP
NL-GF) for Alzheimer's disease (AD) to overcome the problem of overexpression of APP in …