Gene therapy leaves a vicious cycle
R Goswami, G Subramanian, L Silayeva… - Frontiers in …, 2019 - frontiersin.org
The human genetic code encrypted in thousands of genes holds the secret for synthesis of
proteins that drive all biological processes necessary for normal life and death. Though the …
proteins that drive all biological processes necessary for normal life and death. Though the …
Progress in the development of enzyme-based nerve agent bioscavengers
F Nachon, X Brazzolotto, M Trovaslet… - Chemico-biological …, 2013 - Elsevier
Acetylcholinesterase is the physiological target for acute toxicity of nerve agents. Attempts to
protect acetylcholinesterase from phosphylation by nerve agents, is currently achieved by …
protect acetylcholinesterase from phosphylation by nerve agents, is currently achieved by …
Catalytic bioscavengers as countermeasures against organophosphate nerve agents
M Goldsmith, Y Ashani - Chemico-biological interactions, 2018 - Elsevier
Recent years have seen an increasing number of incidence, in which organophosphate
nerve agents (OPNAs) have been used against civilians with devastating outcomes. Current …
nerve agents (OPNAs) have been used against civilians with devastating outcomes. Current …
Emergence of catalytic bioscavengers against organophosphorus agents
P Masson, SV Lushchekina - Chemico-biological interactions, 2016 - Elsevier
Bioscavengers are an effective alternative approach for pre-and post-exposure treatments of
nerve agent (NA) poisoning. Bioscavengers are natural or recombinant enzymes, reactive …
nerve agent (NA) poisoning. Bioscavengers are natural or recombinant enzymes, reactive …
Catalytic bioscavengers: the new generation of bioscavenger-based medical countermeasures
P Masson - Handbook of toxicology of chemical warfare agents, 2015 - Elsevier
The use of bioscavengers of organophosphorus agents (OPs) is the most effective
alternative approach for neutralization or detoxification of OPs for decontamination under …
alternative approach for neutralization or detoxification of OPs for decontamination under …
The effects of repeated low-dose sarin exposure
TM Shih, SW Hulet, JH McDonough - Toxicology and applied …, 2006 - Elsevier
This project assessed the effects of repeated low-dose exposure of guinea pigs to the
organophosphorus nerve agent sarin. Animals were injected once a day, 5 days per week …
organophosphorus nerve agent sarin. Animals were injected once a day, 5 days per week …
An in vitro and in vivo evaluation of the efficacy of recombinant human liver prolidase as a catalytic bioscavenger of chemical warfare nerve agents
PE Rezk, P Zdenka, P Sabnekar, T Kajih… - Drug and Chemical …, 2015 - Taylor & Francis
In this study, we determined the ability of recombinant human liver prolidase to hydrolyze
nerve agents in vitro and its ability to afford protection in vivo in mice. Using adenovirus …
nerve agents in vitro and its ability to afford protection in vivo in mice. Using adenovirus …
Improved hydrolysis of organophosphorus compounds by engineered human prolidases
H Yun, S Lee, S Kim, J Yu, N Lee, J Lee… - Protein and Peptide …, 2017 - ingentaconnect.com
Background: Human prolidase has weak hydrolytic activity for toxic organophosphorus
compounds including diisopropyl fluorophosphates (DFP), chemical warfare nerve agents …
compounds including diisopropyl fluorophosphates (DFP), chemical warfare nerve agents …
Mustard: pathophysiology and therapeutic approaches
D Steinritz, F Balszuweit, H Thiermann, K Kehe - 2016 - books.rsc.org
Sulfur mustard (Sm) or mustard gas [bis (2-chloroethyl) sulphide; CaSrn: 505-60-2] was first
synthesized by Despretz in 1822, and was rediscovered later by Guthrie and niemann. 1, 2 …
synthesized by Despretz in 1822, and was rediscovered later by Guthrie and niemann. 1, 2 …
Recent Trend in Bioscavengers for Inactivation of Toxic Organophosphorus Compounds
H Kim, K Jeong, YS Kye - Applied Chemistry for Engineering, 2020 - koreascience.kr
In recent years, toxic organophosphorus compounds (OPs) have been used for civilians,
becoming a great threat to the world. Alternative to the current treatment policy unpredictable …
becoming a great threat to the world. Alternative to the current treatment policy unpredictable …