Brain tissue is not only one of the most important but also the most complex and compliant
tissue in the human body. While long underestimated, increasing evidence confirms that …

Human pluripotent stem cells have emerged as a promising in vitro model system for
studying the brain. Two-dimensional and three-dimensional cell culture paradigms have …

Human-induced pluripotent stem cells (hiPSCs) have emerged as a promising in vitro model
system for studying neurodevelopment. However, current models remain limited in their …

The biofabrication of three-dimensional (3D) tissues that recapitulate organ-specific
architecture and function would benefit from temporal and spatial control of cell-cell …

The brain is our softest and most vulnerable organ, and understanding its physics is a
challenging but significant task. Throughout the past decade, numerous competing models …

Many biomaterials have been developed which aim to match the elastic modulus of the
brain for improved interfacing. However, other properties such as ultimate toughness, tensile …

Convolutions are a classical hallmark of most mammalian brains. Brain surface morphology
is often associated with intelligence and closely correlated with neurological dysfunction …

Understanding the constitutive behavior of the human brain is critical to interpret the physical
environment during neurodevelopment, neurosurgery, and neurodegeneration. A wide …

Constitutive models are important to biomechanics for two key reasons. First, constitutive
modelling is an essential component of characterizing tissues' mechanical properties for …

We develop a fully data-driven model of anisotropic finite viscoelasticity using neural
ordinary differential equations as building blocks. We replace the Helmholtz free energy …