A significant amount of the fatty acids synthesized by the cytosolic enzyme complex fatty acid
synthase (FAS) or taken up by the diet are further elongated into very long chain fatty acids …

It is generally accepted that dietary linoleate and linolenate are metabolized, respectively, to
5, 8, 11, 14^ 20: 4 and 5, 8, 11, 14, 17^ 20: 5 via the use of positionspeci¢ c v6 and v5 …

Fatty acids are critical for the normal development and function of all organisms, and in
particular, very long chain PUFAs are necessary for the health and maintenance of higher …

The hypothesis that the last step in the biosynthesis of 4, 7, 10, 13, 16, 19-22: 6 from
linolenate is catalyzed by an acyl-CoA-dependent 4-desaturase has never been evaluated …

As precursors of wax compounds, very long chain fatty acids participate in the limitation of
non-stomatal water loss and the prevention of pathogen attacks. They also serve as energy …

B. Coenzyme A derivatives as substrates for microsomal FACES IV. Rv. Ac'nolcs
CATALYZFD BY THE HEPATIC FACES A. The first elongation step: condensation reaction …

Compared with other mammalian tissues, retina is highly enriched in PUFA. Long-chain
PUFA (LC-PUFA; C18-C24) are essential FAs that are enriched in the retina and are …

A sensitive assay for medium chain acyl-CoA dehydrogenase has been developed by
substituting ferricenium hexafluorophosphate for the physiological acceptor, electron …

During the recruitment process of brown adipose tissue, the mRNA level of the fatty acyl
chain elongase Elovl3 is elevated more than 200-fold in cold-stressed mice. We have …

Assay conditions were established for the fatty acid elongation and the A9 desaturase
enzyme systems of bovine liver and adipose tissue microsomes; rat liver microsomes were …