Major depressive disorder (MDD) affects millions of individuals worldwide, leading to
considerable social and economic costs. Despite advancements in pharmacological …

Abstract Treatment-resistant depression (TRD) is a challenging issue to address. Repetitive
transcranial magnetic stimulation (rTMS) is commonly used but shows varying efficacy …

Depression is a common and devastating neuropsychiatric symptom in the elderly and in
patients with dementia. In particular, nearly 80% of patients with Alzheimer's Disease …

The underlying mechanism in both cognitive impairment and depression was chronic
inflammation, which could be reflected by the dietary inflammatory index (DII). However, the …

Traditional Chinese medicine is one of the most commonly used complementary and
alternative medicine therapies for depression. Integrated Chinese-western therapies have …

Objective To determine the efficacy and safety of sertraline in maintenance hemodialysis
(MHD) patients with depression. Methods A randomized controlled trial was conducted …

Selective serotonin reuptake inhibitors (SSRIs) are widely used for depression based on the
monoamine deficiency hypothesis. However, the clinical use of these agents is …

Major depressive disorder (MDD) is strongly associated with type 2 diabetes mellitus
(T2DM). The kynurenine and serotonin pathways, as well as chronic low-grade …

The 5-HT3 receptor and indoleamine 2, 3-dioxygenase 1 (IDO1) enzyme play a crucial role
in the pathogenesis of depression as their activation reduce serotonin contents in the brain …

Introduction: Zuotai is an ancient mineral-herbal mixture containing β-HgS in Tibetan
medicine. It is used to treat nervous system diseases, similar to Chinese medicine cinnabar …