CDS is an underdiagnosed behavioral problem that affects a substantial number of aged
pets. Because changes in behavior are often early indicators of medical or behavior …

According to the WHO, the proportion of people over 60 years is increasing and expected to
reach 22% of total world's population in 2050. In parallel, recent animal demographic …

Appreciation and compassion for welfare and quality of life, as well as emotional and
physical well-being, is important at all stages of our patient's lives, but this becomes …

With increasing age, dogs develop a form of neurodegenerative disease which has many
similarities to age related cognitive impairment and Alzheimer's disease in humans. A …

Practical relevance Cognitive dysfunction syndrome (CDS) is a widely accepted diagnosis in
dogs, with established treatment options. In cats, however, our understanding of cognitive …

This article reviews canine and feline brain aging. Several key features are discussed and
compared, including general aging characteristics and neuropathology. Aging dogs and …

Brain insulin resistance is associated with an increased Aβ production in AD although the
molecular mechanisms underlying this link are still largely unknown. Biliverdin reductase-A …

Aged canines naturally accumulate several types of neuropathology that may have links to
cognitive decline. On a gross level, significant cortical atrophy occurs with age along with an …

In the search for appropriate models for Alzheimer's disease (AD) involving animals other
than rodents, several laboratories are working with animals that naturally develop cognitive …

Cognitive dysfunction syndrome is a major disease affecting old cats and is the
consequence of severe and irreversible loss of brain cells and brain atrophy. The present …