Engineering synthetic biomolecular condensates
The concept of phase-separation-mediated formation of biomolecular condensates provides
a new framework to understand cellular organization and cooperativity-dependent cellular …
a new framework to understand cellular organization and cooperativity-dependent cellular …
Elastin-like polypeptides for biomedical applications
AK Varanko, JC Su, A Chilkoti - Annual review of biomedical …, 2020 - annualreviews.org
Elastin-like polypeptides (ELPs) are stimulus-responsive biopolymers derived from human
elastin. Their unique properties—including lower critical solution temperature phase …
elastin. Their unique properties—including lower critical solution temperature phase …
Elastin‐like polypeptides: biomedical applications of tunable biopolymers
SR MacEwan, A Chilkoti - Peptide Science: Original Research …, 2010 - Wiley Online Library
Artificial repetitive polypeptides have grown in popularity as a bioinspired alternative to
synthetic polymers. The genetically encoded synthesis, monodispersity, potential lack of …
synthetic polymers. The genetically encoded synthesis, monodispersity, potential lack of …
Recursive directional ligation by plasmid reconstruction allows rapid and seamless cloning of oligomeric genes
This paper reports a new strategy, recursive directional ligation by plasmid reconstruction
(PRe-RDL), to rapidly clone highly repetitive polypeptides of any sequence and specified …
(PRe-RDL), to rapidly clone highly repetitive polypeptides of any sequence and specified …
Elastin-like polypeptides: Therapeutic applications for an emerging class of nanomedicines
Elastin-like polypeptides (ELPs) constitute a genetically engineered class of 'protein
polymers' derived from human tropoelastin. They exhibit a reversible phase separation …
polymers' derived from human tropoelastin. They exhibit a reversible phase separation …
Design of Stimuli‐Responsive Peptides and Proteins
Stimuli‐responsive peptides and proteins are an exciting class of smart biomaterials for
various applications and have received significant attention over the past decades. A wide …
various applications and have received significant attention over the past decades. A wide …
Elastin‐like polypeptides as a purification tag for recombinant proteins
W Hassouneh, T Christensen… - Current protocols in …, 2010 - Wiley Online Library
This unit presents a recombinant protein purification method that employs an elastin‐like
polypeptide (ELP) as a purification tag. ELPs undergo a sharp and reversible phase …
polypeptide (ELP) as a purification tag. ELPs undergo a sharp and reversible phase …
Natural and synthetic polymers as drug carriers for delivery of therapeutic proteins
MS Hamid Akash, K Rehman, S Chen - Polymer Reviews, 2015 - Taylor & Francis
In order to cure and treat health-related disorders, therapeutic substance must reach its
target site with a constant concentration over a long period of time. As oral administration is …
target site with a constant concentration over a long period of time. As oral administration is …
Translatable high drug loading drug delivery systems based on biocompatible polymer nanocarriers
Most nanocarriers possess low drug loading, resulting in frequently repeated administration
and thereby high cost and increased side effects. Furthermore, the characteristics of …
and thereby high cost and increased side effects. Furthermore, the characteristics of …
Elastin-like polypeptides revolutionize recombinant protein expression and their biomedical application
DM Floss, K Schallau, S Rose-John, U Conrad… - Trends in …, 2010 - cell.com
Elastin-like polypeptides (ELPs) are highly biocompatible and exhibit a potentially highly
useful property: that of a thermally responsive reversible phase transition. These …
useful property: that of a thermally responsive reversible phase transition. These …