[HTML][HTML] Apolipoprotein E in lipid metabolism and neurodegenerative disease

LG Yang, ZM March, RA Stephenson… - Trends in Endocrinology & …, 2023 - cell.com
Dysregulation of lipid metabolism has emerged as a central component of many
neurodegenerative diseases. Variants of the lipid transport protein, apolipoprotein E …

Brain energy metabolism: astrocytes in neurodegenerative diseases

Z Chen, Z Yuan, S Yang, Y Zhu, M Xue… - CNS neuroscience & …, 2023 - Wiley Online Library
Astrocytes are the most abundant cells in the brain. They have many important functions in
the central nervous system (CNS), including the maintenance of glutamate and ion …

The DDHD2-STXBP1 interaction mediates long-term memory via generation of saturated free fatty acids

IO Akefe, SH Saber, B Matthews, BG Venkatesh… - The EMBO …, 2024 - embopress.org
The phospholipid and free fatty acid (FFA) composition of neuronal membranes plays a
crucial role in learning and memory, but the mechanisms through which neuronal activity …

The uses of transcriptomics and lipidomics indicated that direct contact with graphene oxide altered lipid homeostasis through ER stress in 3D human brain organoids

X Liu, C Yang, P Chen, L Zhang, Y Cao - Science of the Total Environment, 2022 - Elsevier
The potential uses of graphene-based nanomaterials (NMs) in various fields lead to the
concern about their neurotoxicity, considering that graphene-based NMs are capable to …

The potential role of cholesterol in Parkinson's disease neuropathology: perpetrator or victim

M Alrouji, HM Al-Kuraishy, AAA Al-Mahammadawy… - Neurological …, 2023 - Springer
Parkinson's disease (PD) is a neurodegenerative disease characterized by deposition of α-
synuclein and aggregation of Lewy bodies. Cholesterol is involved with PD neuropathology …

Pathophysiology of lipid droplets in neuroglia

T Smolič, R Zorec, N Vardjan - Antioxidants, 2021 - mdpi.com
In recent years, increasing evidence regarding the functional importance of lipid droplets
(LDs), cytoplasmic storage organelles in the central nervous system (CNS), has emerged …

Functions of stress-induced lipid droplets in the nervous system

E Islimye, V Girard, AP Gould - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
Lipid droplets are highly dynamic intracellular organelles that store neutral lipids such as
cholesteryl esters and triacylglycerols. They have recently emerged as key stress response …

Regulation of astrocyte lipid metabolism and ApoE secretion by the microglial oxysterol, 25-hydroxycholesterol

AG Cashikar, D Toral-Rios, D Timm, J Romero… - Journal of lipid …, 2023 - ASBMB
Neuroinflammation, a major hallmark of Alzheimer's disease and several other neurological
and psychiatric disorders, is often associated with dysregulated cholesterol metabolism …

Relationship between thyroid hormones and central nervous system metabolism in physiological and pathological conditions

N Sawicka-Gutaj, N Zawalna, P Gut… - Pharmacological Reports, 2022 - Springer
Thyroid hormones (THs) play an important role in the regulation of energy metabolism. They
also take part in processes associated with the central nervous system (CNS), including …

A high‐fat diet changes astrocytic metabolism to promote synaptic plasticity and behavior

A Popov, N Brazhe, A Fedotova, A Tiaglik… - Acta …, 2022 - Wiley Online Library
Aim A high‐fat diet (HFD) is generally considered to negatively influence the body, the brain,
and cognition. Nonetheless, fat and fatty acids are essential for nourishing and constructing …