Natural nonproteinogenic amino acids vastly outnumber the well-known 22 proteinogenic
amino acids. Such amino acids are generated in specialized metabolic pathways. In these …

Deracemization, which converts a racemate into its single enantiomer without separation of
the intermediate, has gained renewed interest in asymmetric synthesis with its inherent …

Covering: 2011 up to the end of 2021. Fungal nonribosomal peptides (NRPs) and the
related polyketide–nonribosomal peptide hybrid products (PK–NRPs) are a prolific source of …

Covering: up to the end of 2020 Nonribosomal peptide synthetases are remarkable
molecular machines that produce a wide range of structurally complex peptide natural …

The first machineries for non-ribosomal peptide (NRP) biosynthesis were uncovered over 50
years ago, and the dissection of these megasynthetases set the stage for the nomenclature …

Both cis-and trans-tetracyclic spiroindolines are the core of many important biologically
active indole alkaloids, but the divergent synthesis of these important motifs is largely …

Fungal polyketide–nonribosomal peptide (PK–NRP) hybrid macrolactones are a growing
family of natural products with biomedical and agricultural activities. One of the most …

The saprotrophic filamentous fungus Myrothecium inundatum represents a chemically
underexplored ascomycete with a high number of putative biosynthetic gene clusters in its …

Abstract 4 (3 H)-quinazolinone is the core scaffold in more than 200 natural alkaloids and
numerous drugs. Many chemosynthetic methodologies have been developed to generate it; …

Siderophores play a vital role in the viability of fungi and are essential for the virulence of
many pathogenic fungal species. Despite their importance in fungal physiology and …