The emergence of genetic engineering at the beginning of the 1970′ s opened the era of
biomedical technologies, which aims to improve human health using genetic manipulation …

The process of ionic gelation is one of the easiest ways to develop chitosan nanoparticles
reported so far in the literature. Its success is mainly due to its one-shot synthesis, and to the …

Healing enhancement and pain control are critical issues on wound management. So far,
different wound dressings have been developed. Among them, hydrogels are the most …

Recently, bone tissue engineering emerged as a viable therapeutic alternative, comprising
bone implants and new personalized scaffolds to be used in bone replacement and …

Therapeutic application of nucleic acids requires their encapsulation in nanosized carriers
that enable safe and efficient intracellular delivery. Before the desired site of action is …

Non-viral gene delivery vectors have lagged far behind viral ones in the current pipeline of
clinical trials of gene therapy nanomedicines. Even when non-viral nanovectors pose less …

ABSTRACT Three‐dimensional (3D) cell culture models of solid tumors are currently having
a tremendous impact in the in vitro screening of candidate anti‐tumoral therapies. These 3D …

Introduction: Nucleic-acid-based biopharmaceuticals enclose a remarkable potential for
treating debilitating or life-threatening diseases that currently remain incurable. This …

The co-delivery of minicircle DNA (mcDNA) and small anti-cancer drugs via stimuli-sensitive
nanocarriers is a promising approach for combinatorial cancer therapy. However, the …

Optimal cell therapies require efficient, selective and rapid delivery of molecular cargo into
target cells without compromising their viability. Achieving these goals ex vivo in bulk …