The primary objective of implementing Electronic Health Records (EHRs) is to improve the
management of patients' health-related information. However, these records have also been …

Considerable efforts have been made since the 1950s to better understand the cellular and
molecular mechanisms of action of metformin, a potent antihyperglycaemic agent now …

Two general approaches to the treatment of type 2 diabetes mellitus (T2DM) have been
advocated. 1) A “guideline” approach that advocates sequential addition of antidiabetes …

Type 2 diabetes mellitus (T2DM) is characterized by multiple pathophysiologic
abnormalities. With time, multiple glucose-lowering medications are commonly required to …

Aims The impact of insulin secretagogues (ISs) on long-term major clinical outcomes in type
2 diabetes remains unclear. We examined mortality and cardiovascular risk associated with …

Background Sulfonylureas are common second-line options for management of type 2
diabetes; however, they are associated with a higher risk of cardiovascular events compared …

Background: The effects of sulfonylureas and metformin on outcomes of cardiovascular
disease (CVD) in type 2 diabetes are not well-characterized. Objective: To compare the …

Recent randomized trials have compared the newer antidiabetic agents to treatments
involving sulfonylureas, drugs associated with increased cardiovascular risks and mortality …

This guideline refers primarily to type 2 diabetes in the older person. There is limited
information on the management of type 1 diabetes in the elderly, but this is included …

Since their introduction in clinical practice in the 1950's, Sulfonylureas (SUs) have remained
the main-stay of pharmacotherapy in the management of type 2 diabetes. Despite their well …