Antifibrinolytic drugs are routinely used worldwide to reduce the bleeding that results from a
wide range of hemorrhagic conditions. The most commonly used antifibrinolytic drug …

Tranexamic acid (TXA) is an antifibrinolytic agent commonly used for the treatment or
prevention of bleeding. Indications for TXA are diverse, including heavy menstrual bleeding …

Purpose To investigate the incidence rate of tranexamic acid (TXA)-associated seizures.
Methods Two electronic databases (Medline and Embase) were searched. We looked for …

Antifibrinolytic therapy reduces bleeding and chest tube drainage output in cardiac surgical
patients but is associated with potential side effects. Two phase-II studies with new …

Critically ill children with acute neurologic dysfunction are at risk for a variety of
complications that can be detected by noninvasive bedside neuromonitoring. Continuous …

Neurologic complications, associated with cardiac surgery and cardiopulmonary bypass
(CPB) in adults, are common and can be devastating in some cases. This comprehensive …

Continuous electroencephalography uncovers a clinically underappreciated burden of
subtle and nonconvulsive status epilepticus in critically ill patients. Prolonged recordings …

Purpose Excessive bleeding is an acknowledged consequence of cardiac surgery,
occurring in up to 10% of adult patients. This clinically important complication leads to …

Background Tranexamic acid (TxA) reduces perioperative blood transfusion in cardiac
surgery; however, the optimal dose of TxA remains unknown. Methods and results This large …

Neurological complications after heart surgery are associated with tremendous morbidity
and mortality. Nonconvulsive status epilepticus (NCSE), which can only be verified by EEG …