Transcriptional regulation of catabolic pathways is a central mechanism by which cells
respond to physiological cues to generate the energy required for anabolic pathways …

Mitochondria are the source of cellular energy production and are present in different types
of cells. However, their function is especially important for the heart due to the high demands …

The loss of dopamine (DA) neurons within the substantia nigra pars compacta (SNpc) is a
defining pathological hallmark of Parkinson's disease (PD). Nevertheless, the molecular …

Natural mitochondrial DNA (mtDNA) mutations enable the inference of clonal relationships
among cells. mtDNA can be profiled along with measures of cell state, but has not yet been …

A large body of evidence indicates that mitochondrial dysfunction has a major role in the
pathogenesis of multiple cardiovascular disorders. Over the past 2 decades, extraordinary …

High mortality rates due to cardiovascular diseases (CVDs) have attracted worldwide
attention. It has been reported that mitochondrial dysfunction is one of the most important …

The accumulation of excess reactive oxygen species (ROS) can lead to oxidative stress
(OS), which can induce gene mutations, protein denaturation, and lipid peroxidation directly …

Rationale: Diabetic cardiomyopathy (DbCM) is a major complication in type-1 diabetes,
accompanied by altered cardiac energetics, impaired mitochondrial function, and oxidative …

The heart requires fatty acids to maintain its activity. Various mechanisms regulate
myocardial fatty acid metabolism, such as energy production using fatty acids as fuel, for …

Hematologic malignancies are frequently associated with cardiac pathologies. Mutations of
isocitrate dehydrogenase 1 and 2 (IDH1/2) occur in a subset of acute myeloid leukemia …