Recent advances in single molecule experiments have raised many challenges. These
challenges can be met by a proper understanding of the inter-and intra-molecular …

The cluster variation method (CVM) is a hierarchy of approximate variational techniques for
discrete (Ising-like) models in equilibrium statistical mechanics, improving on the mean-field …

Recent breakthroughs in highly accurate protein structure prediction using deep neural
networks have made considerable progress in solving the structure prediction component of …

Diffusion on a low-dimensional free-energy surface is a remarkably successful model for the
folding dynamics of small single-domain proteins. Complicating the interpretation of both …

Nanosecond laser T-jump was used to measure the viscosity dependence of the folding
kinetics of the villin subdomain under conditions where the viscogen has no effect on its …

Advances in computing have enabled microsecond all-atom molecular dynamics trajectories
of protein folding that can be used to compare with and test critical assumptions of …

Background The aqueous environment directs the protein folding process towards the
generation of micelle-type structures, which results in the exposure of hydrophilic residues …

A combinatorial approach has been used to determine the optimal assumptions and
robustness of simple statistical mechanical models for protein folding. By combining …

The consistency of energy landscape theory predictions with available experimental data, as
well as direct evidence from molecular simulations, have shown that protein folding …

Charged residues on the surface of a protein are known hot-spots for post-translational
modification, protein/ligand-binding, and tuning conformational stabilities. Recent …