[HTML][HTML] Gut microbiota-derived short-chain fatty acids and hypertension: Mechanism and treatment

F Yang, H Chen, Y Gao, N An, X Li, X Pan… - Biomedicine & …, 2020 - Elsevier
Hypertension (HTN) is an growing emerging health issue around across the world. In recent
years, increasing attention has been paid to the role of dysbacteriosis in HTN and its …

Gut–brain axis in regulation of blood pressure

T Yang, J Zubcevic - Frontiers in physiology, 2017 - frontiersin.org
Hypertension (HTN) is an escalating health issue worldwide. It is estimated that 1.56 billion
people will suffer from high blood pressure (BP) by 2025. Recent studies reported an …

[HTML][HTML] Microglia, autonomic nervous system, immunity and hypertension: is there a link?

Y Li, B Wei, X Liu, XZ Shen, P Shi - Pharmacological research, 2020 - Elsevier
Hypertension ranks the most common risk factor for cardiovascular diseases, and it affects
almost one third of adult population globally. Emerging evidence indicates that immune …

Increased abundance of lactobacillales in the colon of beta-adrenergic receptor knock out mouse is associated with increased gut bacterial production of short chain …

A Bartley, T Yang, R Arocha, WL Malphurs… - Frontiers in …, 2018 - frontiersin.org
Emerging evidence suggests an associative link between gut dysbiosis, the autonomic
nervous system (ANS) and the immune system in pathophysiology of neurogenic …

Immune cell β2-adrenergic receptors contribute to the development of heart failure

MA Tanner, CA Maitz… - American Journal of …, 2021 - journals.physiology.org
β-Adrenergic receptors (βARs) regulate normal and pathophysiological heart function
through their impact on contractility. βARs are also regulators of immune function where they …

Brain-Splenic Immune System Interactions in Hypertension: Cellular and Molecular Mechanisms

S Perrotta, D Carnevale - Arteriosclerosis, Thrombosis, and …, 2024 - Am Heart Assoc
Hypertension represents a major worldwide cause of death and disability, and it is becoming
increasingly clear that available therapies are not sufficient to reduce the risk of major …

Autonomic regulation of T-lymphocytes: Implications in cardiovascular disease

SK Elkhatib, AJ Case - Pharmacological research, 2019 - Elsevier
The nervous and immune systems both serve as essential assessors and regulators of
physiological function. Recently, there has been a great interest in how the nervous and …

A single angiotensin II hypertensive stimulus is associated with prolonged neuronal and immune system activation in Wistar-Kyoto rats

J Zubcevic, MM Santisteban, PD Perez… - Frontiers in …, 2017 - frontiersin.org
Activation of autonomic neural pathways by chronic hypertensive stimuli plays a significant
role in pathogenesis of hypertension. Here, we proposed that even a single acute …

Shifts in the gut microbiota composition due to depleted bone marrow beta adrenergic signaling are associated with suppressed inflammatory transcriptional networks …

T Yang, N Ahmari, JT Schmidt, T Redler… - Frontiers in …, 2017 - frontiersin.org
The brain-gut axis plays a critical role in the regulation of different diseases, many of which
are characterized by sympathetic dysregulation. However, a direct link between sympathetic …

Conditional deletion of Adrb2 in mesenchymal stem cells attenuates osteoarthritis-like defects in temporomandibular joint

J Sun, J Yan, J Li, W Wang, S Yu, H Zhang, F Huang… - Bone, 2020 - Elsevier
Abstract β2-adrenergic signal transduction in mesenchymal stem cells (MSCs) induces
subchondral bone loss in osteoarthritis (OA) of temporomandibular joints (TMJs). However …